PDB
8JSO
Resolution
3.4 Å
Released
Nov. 15, 2023
Receptor
TA1
Class
A
Species
Homo sapiens
Ligand
Function
dexamfetamine
Agonist
Reference
10.1038/S41586-023-06804-Z

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Ligand Amino Acid Generic Number Segment Interaction Type
dexamfetamine D103 3.32x32 TM3 polar (charge-charge)
dexamfetamine D103 3.32x32 TM3 polar (hydrogen bond)
dexamfetamine I104 3.33x33 TM3 Van der Waals
dexamfetamine S107 3.36x36 TM3 Van der Waals
dexamfetamine F186 ECL2 hydrophobic
dexamfetamine T194 5.42x43 TM5 hydrophobic
dexamfetamine S198 5.46x461 TM5 Van der Waals
dexamfetamine W264 6.48x48 TM6 Van der Waals
dexamfetamine F267 6.51x51 TM6 aromatic (edge-to-face)
dexamfetamine F267 6.51x51 TM6 hydrophobic
dexamfetamine F268 6.52x52 TM6 aromatic (edge-to-face)
dexamfetamine F268 6.52x52 TM6 hydrophobic
dexamfetamine I290 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K Q L H ICL1ECL1 C W Y F ECL1ICL2 P L R Y K A K M ICL2ECL2 L N F K G A E E I Y Y K H V H C R G G C S V F F ECL2ICL3 I G L E M K ICL3ECL3 H Y I I ECL3N-term M M P F C H N I I N I S C V K N N W S N N-termC-term G K I F Q K D S S R C K L F L E L S S C-term D V R A S L Y S L M V L I I L T T L V G N L I V I V S I S H F T P T N W L I H S M A T V D F L L G C L V M P Y S M V R S A E H G E V F C K I H T S T D I M L S S A S I F H L S F I S I D R Y Y A V C D N I L V I C V M I F I S W S V P A V F A F G M I F L E S K I S G V L T F M T S F Y I P G S I M L C V Y Y R I Y L I A K E Q A R L I S D A N Q K L Q N G I S Q S K E R K A V K T L G I V M G V F L I C W C P F F I C T V M D P F L P P T L N D V L I W F G Y L N S T F N P M V Y A F F Y P W L K M F R K A M L F
Helix box plot — Download: PNG | SVG L N G V L T T L I I L V M L S Y L S A R 1 H S M A T V D F L L G L C V M P Y S M V R 2 F S L H F I S A S S L M I D T S T H I K 3 I C V M I F I S W S V P A V F A F G M I 4 Y V C L M I S G P I Y F S T M F T L V G S 5 G I V M G V F L I C W C P F F I C T V M 6 M P N F T S N L Y G F W I L V D N L T 7

GPCRdb(A)
GPCRdb(A)
TA1 receptor
TM3
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 S107
TM5
5x43 5.42x43 T194
5x461 5.46x461 S198
TM6
6x48 6.48x48 W264
6x51 6.51x51 F267
6x52 6.52x52 F268
TM7
7x38 7.39x38 I290