PDB
8JSP
Resolution
3.7 Å
Released
Nov. 15, 2023
Receptor
5-HT1A
Class
A
Species
Homo sapiens
Ligand
ulotaront
Function
Agonist
Reference
10.1038/S41586-023-06804-Z

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Ligand Amino Acid Generic Number Segment Interaction Type
ulotaront T121 3.37x37 TM3 polar (hydrogen bond)
ulotaront S199 5.42x43 TM5 Van der Waals
ulotaront A203 5.46x461 TM5 Van der Waals
ulotaront F361 6.51x51 TM6 hydrophobic
ulotaront F361 6.51x51 TM6 Van der Waals
ulotaront F362 6.52x52 TM6 aromatic (edge-to-face)
ulotaront F362 6.52x52 TM6 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R S L Q ICL1ECL1 K W T L ECL1ICL2 P I D Y V N K R ICL2ECL2 R T P E D R S D P D A C T I S K ECL2ICL3 E K T G A D T R H G A S P A P Q P K K S V N G E S G S R N W R L G V E S K A G G A L C A N G A V R Q G D D G A A L E V I E V H R V G N S K E H L P L P S E A G P T P C A P A S F E R ICL3ECL3 E S S C H M ECL3N-term M D V L S P G Q G N N T T S P P A P F E T G G N T T G I S D V N-termC-term K C K F C R Q C-term T V S Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N G Q V T C D L F I A L D V L C C T S S I L H L C A I A L D R Y W A I T D T P R R A A A L I S L T W L I G F L I S I P P M L G W D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K T V K K V K N E R N A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F K K F Q N A I I
Helix box plot — Download: PNG | SVG A N G L V A C F I L T G L L L S T I V Q 1 G S L A V T D L M V S L V V L P M A A L Y 2 A C L H L I S S T C C L V D L A I F L D 3 A A A L I S L T W L I G F L I S I P P M 4 Y L V L M L L L P I Y F A G F T S Y I T Y 5 G I I M G T F I L C W L P F F I V A L V 6 V P N L L S N S Y G L W N I I A G L L 7

GPCRdb(A)
GPCRdb(A)
5-HT1A receptor
TM3
3x37 3.37x37 T121
TM5
5x43 5.42x43 S199
5x461 5.46x461 A203
TM6
6x51 6.51x51 F361
6x52 6.52x52 F362