PDB
8JXR
Resolution
3.6 Å
Released
Sept. 4, 2024
Receptor
D1
Class
A
Species
Homo sapiens
Ligand
(+)-LSD
Function
Agonist
Reference
10.1016/J.NEURON.2024.07.003

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
(+)-LSD W99 3.28x28 TM3 hydrophobic
(+)-LSD D103 3.32x32 TM3 polar (charge-assisted hydrogen bond)
(+)-LSD I104 3.33x33 TM3 hydrophobic
(+)-LSD I104 3.33x33 TM3 Van der Waals
(+)-LSD S107 3.36x36 TM3 Van der Waals
(+)-LSD S198 5.42x43 TM5 Van der Waals
(+)-LSD W285 6.48x48 TM6 Van der Waals
(+)-LSD W285 6.48x48 TM6 hydrophobic
(+)-LSD F288 6.51x51 TM6 Van der Waals
(+)-LSD F288 6.51x51 TM6 aromatic (edge-to-face)
(+)-LSD F289 6.52x52 TM6 hydrophobic
(+)-LSD F289 6.52x52 TM6 Van der Waals
(+)-LSD N292 6.55x55 TM6 Van der Waals
(+)-LSD F313 7.35x34 TM7 hydrophobic
(+)-LSD F313 7.35x34 TM7 Van der Waals
(+)-LSD V317 7.39x38 TM7 Van der Waals
(+)-LSD V317 7.39x38 TM7 hydrophobic
(+)-LSD W321 7.43x42 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 R H L R S ICL1ECL1 F W P F ECL1ICL2 P F R Y E R K M ICL2ECL2 W H K A K P T S P S D G N A T S L A E T I D N C D S S L ECL2ICL3 T T T G N G K P V E C S Q P E S S F ICL3ECL3 G S G E T Q P F C I ECL3N-term M R T L N T S A M D G T G L V V E R D F N-termC-term C Y R L C P A T N N A I E T V S I N N N G A A M F S S H H E P R G S I S K E C N L V Y L I P H A V G S S E D L K K E E A A G I A R P L E K L S P A L S V I L D Y D T D V S L E K I Q P I T Q N G Q H P T C-term S V R I L T A C F L S L L I L S T L L G N T L V C A A V I R F K V T N F F V I S L A V S D L L V A V L V M P W K A V A E I A G G S F C N I W V A F D I M C S T A S I L N L C V I S V D R Y W A I S S T P K A A F I L I S V A W T L S V L I S F I P V Q L S S R T Y A I S S S V I S F Y I P V A I M I V T Y T R I Y R I A Q K Q I R R I A A L E R A A V H A K N C Q K M S F K R E T K V L K T L S V I M G V F V C C W L P F F I L N C I L P F C D S N T F D V F V W F G W A N S S L N P I I Y A F N A D F S T F R K A L L G
Helix box plot — Download: PNG | SVG T N G L L T S L I L L S L F C A T L I R 1 I S L A V S D L L V A L V V M P W K A V A 2 V C L N L I S A T S C M I D F A V W I N 3 A F I L I S V A W T L S V L I S F I P V 4 Y T V I M I A V P I Y F S I V S S S I A Y 5 S V I M G V F V C C W L P F F I L N C I 6 I P N L S S N A W G F W V F V D F T N 7

GPCRdb(A)
GPCRdb(A)
D1 receptor
TM3
3x28 3.28x28 W99
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 S107
TM5
5x43 5.42x43 S198
TM6
6x48 6.48x48 W285
6x51 6.51x51 F288
6x52 6.52x52 F289
6x55 6.55x55 N292
TM7
7x34 7.35x34 F313
7x38 7.39x38 V317
7x42 7.43x42 W321