Structure information

CXCR4

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8K3Z

SPECIES

Homo sapiens

RESOLUTION

2.810

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

July 17, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Stromal cell-derived factor 1 P27 N-term hydrophobic
Stromal cell-derived factor 1 C28 N-term polar (hydrogen bond with backbone)
Stromal cell-derived factor 1 C28 N-term Van der Waals
Stromal cell-derived factor 1 F29 N-term hydrophobic
Stromal cell-derived factor 1 F29 N-term Van der Waals
Stromal cell-derived factor 1 R30 N-term Van der Waals
Stromal cell-derived factor 1 Y45 1.39x39 TM1 Van der Waals
Stromal cell-derived factor 1 W94 2.60x60 TM2 Van der Waals
Stromal cell-derived factor 1 W94 2.60x60 TM2 hydrophobic
Stromal cell-derived factor 1 H113 3.29x29 TM3 Van der Waals
Stromal cell-derived factor 1 Y116 3.32x32 TM3 Van der Waals
Stromal cell-derived factor 1 Y116 3.32x32 TM3 hydrophobic
Stromal cell-derived factor 1 S178 ECL2 polar (hydrogen bond)
Stromal cell-derived factor 1 S178 ECL2 Van der Waals
Stromal cell-derived factor 1 I185 ECL2 hydrophobic
Stromal cell-derived factor 1 I185 ECL2 Van der Waals
Stromal cell-derived factor 1 C186 45.50x50 ECL2 polar (hydrogen bond with backbone)
Stromal cell-derived factor 1 C186 45.50x50 ECL2 Van der Waals
Stromal cell-derived factor 1 D187 45.51x51 ECL2 polar (charge-assisted hydrogen bond)
Stromal cell-derived factor 1 F189 ECL2 Van der Waals
Stromal cell-derived factor 1 F189 ECL2 hydrophobic
Stromal cell-derived factor 1 Y190 ECL2 Van der Waals
Stromal cell-derived factor 1 Y190 ECL2 polar (hydrogen bond with backbone)
Stromal cell-derived factor 1 I259 6.55x55 TM6 hydrophobic
Stromal cell-derived factor 1 I259 6.55x55 TM6 Van der Waals
Stromal cell-derived factor 1 D262 6.58x58 TM6 polar (charge-assisted hydrogen bond)
Stromal cell-derived factor 1 L266 6.62x62 TM6 Van der Waals
Stromal cell-derived factor 1 E268 6.64x64 TM6 Van der Waals
Stromal cell-derived factor 1 H281 7.32x31 TM7 polar (hydrogen bond)
Stromal cell-derived factor 1 H281 7.32x31 TM7 Van der Waals
Stromal cell-derived factor 1 S285 7.36x35 TM7 Van der Waals
Stromal cell-derived factor 1 E288 7.39x38 TM7 polar (charge-assisted hydrogen bond)
Stromal cell-derived factor 1 F292 7.43x42 TM7 hydrophobic

Ligands

Stromal cell-derived factor 1

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Residue Diagrams

G N G V I G T L F I I S Y I T P L F I K 1 L H L S V A D L L F V I T L P F W A V D 2 F A L I L V S S Y L N V T Y I V H V A K 3 E K V V Y V G V W I P A L L L T I P D 4 Y C S L I V I G P L I L G V M I H Q F Q F 5 V I L I L A F F A C W L P Y Y I G I S I 6 I P N L C C H F F A L A E T I S I W K 7
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ICL1 K K L R ICL1ECL1 N W Y F ECL1ICL2 A T N S Q R P R ICL2ECL2 N V S E A D D R Y I C D R F Y P N ECL2ICL3 K G H Q ICL3ECL3 I I K Q ECL3N-term M E G I S I Y T S D N Y T E E M G S G D Y D S M K E P C F N-termC-term S V S R G S S L K I L S K G K R G G H S S V S T E S E S S S F H S S C-term R E E N A N F N K I F L P T I Y S I I F L T G I V G N G L V I L V M G Y Q S M T D K Y R L H L S V A D L L F V I T L P F W A V D A V A G N F L C K A V H V I Y T V N L Y S S V L I L A F I S L D R Y L A I V H K L L A E K V V Y V G V W I P A L L L T I P D F I F A D L W V V V F Q F Q H I M V G L I L P G I V I L S C Y C I I I S K L S H S K R K A L K T T V I L I L A F F A C W L P Y Y I G I S I D S F I L L E G C E F E N T V H K W I S I T E A L A F F H C C L N P I L Y A F L G A K A Q H F K T S A L T
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Residue Table


GPCRdb(A)
GPCRdb(A)
CXCR4
TM1
1x39 1.39x39 Y45
TM2
2x60 2.60x60 W94
TM3
3x29 3.29x29 H113
3x32 3.32x32 Y116
ECL2
45x50 45.50x50 C186
45x51 45.51x51 D187
TM6
6x55 6.55x55 I259
6x58 6.58x58 D262
6x62 6.62x62 L266
6x64 6.64x64 E268
TM7
7x31 7.32x31 H281
7x35 7.36x35 S285
7x38 7.39x38 E288
7x42 7.43x42 F292