PDB
8K4S
Resolution
2.9 Å
Released
Nov. 6, 2024
Receptor
MRGPRX4
Class
A
Species
Homo sapiens
Ligand
DCA-3P
Function
Agonist
Reference
10.1016/J.CELL.2024.10.001

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Ligand Amino Acid Generic Number Segment Interaction Type
DCA-3P V99 3.29x29 TM3 hydrophobic
DCA-3P F107 3.37x37 TM3 hydrophobic
DCA-3P L156 ECL2 hydrophobic
DCA-3P I239 ECL3 hydrophobic
DCA-3P Y240 ECL3 hydrophobic
DCA-3P L246 ECL3 hydrophobic
DCA-3P Y254 7.35x34 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 R R ICL1ECL1 I N I ECL1ICL2 P I W Y R C R R P T ICL2ECL2 D F L F S G A ECL2ICL3 G S R K M ICL3ECL3 I Y R M H L N L E ECL3N-term M D P T V P V F G T K L T P I N G R E E T P C Y N N-termC-term Q R Q N R Q N L K L V L Q R A L Q D K P E V D K G E G Q L P E E S L E L S G S R L G P C-term Q T L S F T V L T C I I S L V G L T G N A V V L W L L G Y R M N A V S I Y I L N L A A A D F L F L S F Q I I R L P L R L S H L I R K I L V S V M T F P Y F T G L S M L S A I S T E R C L S V L W H L S A V V C V L L W G L S L L F S M L E W R F C D S S W C E T S D F I P V A W L I F L C V V L C V S S L V L L V R I L C P L T R L Y V T I L L T V L V F L L C G L P F G I L G A L V L Y C H V Y L V C M S L S S L N S S A N P I I Y F F V G S F R
Helix box plot — Download: PNG | SVG A N G T L G V L S I I C T L V T F S L T 1 L N L A A A D F L F L S F Q I I R L P L 2 A S L M S L G T F Y P F T M V S V L I K 3 S A V V C V L L W G L S L L F S M L E W 4 S S V C L V V C L F I L W A V P I F D S 5 L L T V L V F L L C G L P F G I L G A L 6 I P N A S S N L S S L S M C V L Y V H 7

GPCRdb(A)
GPCRdb(A)
MRGPRX4
TM3
3x29 3.29x29 V99
3x37 3.37x37 F107
TM7
7x34 7.35x34 Y254