PDB
8K6O
Resolution
3.3 Å
Released
July 31, 2024
Receptor
Y1
Class
A
Species
Homo sapiens
Ligand
Function
[Leu31, Pro34]-NPY
Agonist
Reference
—

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
[Leu31, Pro34]-NPY T97 2.61x60 TM2 hydrophobic
[Leu31, Pro34]-NPY Y100 2.64x63 TM2 polar (hydrogen bond)
[Leu31, Pro34]-NPY T101 2.65x64 TM2 Van der Waals
[Leu31, Pro34]-NPY D104 ECL1 hydrophobic
[Leu31, Pro34]-NPY Q120 3.32x32 TM3 Van der Waals
[Leu31, Pro34]-NPY I124 3.36x36 TM3 hydrophobic
[Leu31, Pro34]-NPY F173 4.60x61 TM4 Van der Waals
[Leu31, Pro34]-NPY F184 ECL2 hydrophobic
[Leu31, Pro34]-NPY N186 ECL2 Van der Waals
[Leu31, Pro34]-NPY V187 ECL2 polar (hydrogen bond with backbone)
[Leu31, Pro34]-NPY V187 ECL2 hydrophobic
[Leu31, Pro34]-NPY T188 ECL2 Van der Waals
[Leu31, Pro34]-NPY L189 ECL2 hydrophobic
[Leu31, Pro34]-NPY V197 ECL2 hydrophobic
[Leu31, Pro34]-NPY F199 45.51x51 ECL2 Van der Waals
[Leu31, Pro34]-NPY D205 5.32x33 TM5 polar (charge-charge)
[Leu31, Pro34]-NPY R208 5.35x36 TM5 Van der Waals
[Leu31, Pro34]-NPY T212 5.39x40 TM5 polar (hydrogen bond)
[Leu31, Pro34]-NPY L215 5.42x43 TM5 Van der Waals
[Leu31, Pro34]-NPY Q219 5.46x461 TM5 polar (hydrogen bond)
[Leu31, Pro34]-NPY N283 6.55x55 TM6 polar (hydrogen bond)
[Leu31, Pro34]-NPY F286 6.58x58 TM6 aromatic (pi-cation)
[Leu31, Pro34]-NPY D287 6.59x59 TM6 polar (charge-charge)
[Leu31, Pro34]-NPY H290 ECL3 aromatic (pi-cation)
[Leu31, Pro34]-NPY A294 ECL3 Van der Waals
[Leu31, Pro34]-NPY C296 ECL3 Van der Waals
[Leu31, Pro34]-NPY H298 7.31x30 TM7 Van der Waals
[Leu31, Pro34]-NPY N299 7.32x31 TM7 Van der Waals
[Leu31, Pro34]-NPY F302 7.35x34 TM7 hydrophobic
[Leu31, Pro34]-NPY H306 7.39x38 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 K E M R ICL1ECL1 H W V F ECL1ICL2 P R G W R P ICL2ECL2 V M T D E P F Q N V T L D A Y K D K Y V C F D Q F P ECL2ICL3 K M R ICL3ECL3 H Q I I A ECL3N-term M N S T L F S Q V E N H S V H S N F S E K N A Q L L A F E N D D C H L N-termC-term N F C D F R S R D D D Y E T I A M S T M H T D V S K T S L K Q A S P V A F K K I N N N D D N E K I C-term P L A M I F T L A L A Y G A V I I L G V S G N L A L I I I I L K Q N V T N I L I V N L S F S D L L V A I M C L P F T F V Y T L M D G E A M C K L N P F V Q C V S I T V S I F S L V L I A V E R H Q L I I N N N R H A Y V G I A V I W V L A V A S S L P F L I Y Q S D S H R L S Y T T L L L V L Q Y F G P L C F I F I C Y F K I Y I R L K R R N N M M D D N K Y R S S E T K R I N I M L L S I V V A F A V C W L P L T I F N T V F D W N T C N H N L L F L L C H L T A M I S T C V N P I F Y G F L N K N L Q F F Q R D F F
Helix box plot — Download: PNG | SVG L N G S V G L I I V A G Y A L A L T F I 1 V N L S F S D L L V A M I C L P F T F V Y 2 L V L S F I S V T I S V C Q V F P N L K 3 A Y V G I A V I W V L A V A S S L P F 4 Y C I F I F C L P G F Y Q L V L L L T T Y 5 L S I V V A F A V C W L P L T I F N T V 6 I P N V C T S I M A T L H C L L F L L 7

GPCRdb(A)
GPCRdb(A)
Y1 receptor
TM2
2x60 2.61x60 T97
2x63 2.64x63 Y100
2x64 2.65x64 T101
TM3
3x32 3.32x32 Q120
3x36 3.36x36 I124
TM4
4x61 4.60x61 F173
ECL2
45x51 45.51x51 F199
TM5
5x33 5.32x33 D205
5x36 5.35x36 R208
5x40 5.39x40 T212
5x43 5.42x43 L215
5x461 5.46x461 Q219
TM6
6x55 6.55x55 N283
6x58 6.58x58 F286
6x59 6.59x59 D287
TM7
7x30 7.31x30 H298
7x31 7.32x31 N299
7x34 7.35x34 F302
7x38 7.39x38 H306