Structure information

Y1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8K6O

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

D

REFERENCE

PUBLICATION DATE

July 31, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
neuropeptide Y Y100 2.64x63 TM2 Van der Waals
neuropeptide Y Y100 2.64x63 TM2 polar (hydrogen bond)
neuropeptide Y Y100 2.64x63 TM2 polar (hydrogen bond with backbone)
neuropeptide Y T101 2.65x64 TM2 polar (hydrogen bond with backbone)
neuropeptide Y T101 2.65x64 TM2 Van der Waals
neuropeptide Y D104 ECL1 Van der Waals
neuropeptide Y I124 3.36x36 TM3 Van der Waals
neuropeptide Y I124 3.36x36 TM3 hydrophobic
neuropeptide Y F184 ECL2 hydrophobic
neuropeptide Y F184 ECL2 Van der Waals
neuropeptide Y N186 ECL2 polar (hydrogen bond)
neuropeptide Y V187 ECL2 polar (hydrogen bond with backbone)
neuropeptide Y V187 ECL2 Van der Waals
neuropeptide Y T188 ECL2 polar (hydrogen bond)
neuropeptide Y F199 45.51x51 ECL2 Van der Waals
neuropeptide Y R208 5.35x36 TM5 Van der Waals
neuropeptide Y T212 5.39x40 TM5 polar (hydrogen bond)
neuropeptide Y T212 5.39x40 TM5 Van der Waals
neuropeptide Y Q219 5.46x461 TM5 polar (hydrogen bond)
neuropeptide Y Q219 5.46x461 TM5 polar (hydrogen bond)
neuropeptide Y N283 6.55x55 TM6 polar (hydrogen bond)
neuropeptide Y F286 6.58x58 TM6 hydrophobic
neuropeptide Y D287 6.59x59 TM6 Van der Waals
neuropeptide Y H290 ECL3 polar (hydrogen bond)
neuropeptide Y H290 ECL3 polar (hydrogen bond)
neuropeptide Y A294 ECL3 Van der Waals
neuropeptide Y C296 ECL3 Van der Waals
neuropeptide Y H298 7.31x30 TM7 Van der Waals
neuropeptide Y N299 7.32x31 TM7 Van der Waals
neuropeptide Y F302 7.35x34 TM7 hydrophobic
neuropeptide Y F302 7.35x34 TM7 Van der Waals
neuropeptide Y H306 7.39x38 TM7 polar (hydrogen bond)
neuropeptide Y H306 7.39x38 TM7 Van der Waals

Ligands

neuropeptide Y

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Residue Diagrams

L N G S V G L I I V A G Y A L A L T F I 1 V N L S F S D L L V A M I C L P F T F V Y 2 L V L S F I S V T I S V C Q V F P N L K 3 A Y V G I A V I W V L A V A S S L P F 4 Y C I F I F C L P G F Y Q L V L L L T T Y 5 L S I V V A F A V C W L P L T I F N T V 6 I P N V C T S I M A T L H C L L F L L 7
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ICL1 K E M R ICL1ECL1 H W V F ECL1ICL2 P R G W R P ICL2ECL2 V M T D E P F Q N V T L D A Y K D K Y V C F D Q F P ECL2ICL3 K M R ICL3ECL3 H Q I I A ECL3N-term M N S T L F S Q V E N H S V H S N F S E K N A Q L L A F E N D D C H L N-termC-term N F C D F R S R D D D Y E T I A M S T M H T D V S K T S L K Q A S P V A F K K I N N N D D N E K I C-term P L A M I F T L A L A Y G A V I I L G V S G N L A L I I I I L K Q N V T N I L I V N L S F S D L L V A I M C L P F T F V Y T L M D G E A M C K L N P F V Q C V S I T V S I F S L V L I A V E R H Q L I I N N N R H A Y V G I A V I W V L A V A S S L P F L I Y Q S D S H R L S Y T T L L L V L Q Y F G P L C F I F I C Y F K I Y I R L K R R N N M M D D N K Y R S S E T K R I N I M L L S I V V A F A V C W L P L T I F N T V F D W N T C N H N L L F L L C H L T A M I S T C V N P I F Y G F L N K N L Q F F Q R D F F
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Residue Table


GPCRdb(A)
GPCRdb(A)
Y1 receptor
TM2
2x63 2.64x63 Y100
2x64 2.65x64 T101
TM3
3x36 3.36x36 I124
ECL2
45x51 45.51x51 F199
TM5
5x36 5.35x36 R208
5x40 5.39x40 T212
5x461 5.46x461 Q219
TM6
6x55 6.55x55 N283
6x58 6.58x58 F286
6x59 6.59x59 D287
TM7
7x30 7.31x30 H298
7x31 7.32x31 N299
7x34 7.35x34 F302
7x38 7.39x38 H306