PDB
8K8J
Resolution
2.9 Å
Released
Feb. 14, 2024
Receptor
CB1
Class
A
Species
Homo sapiens
Ligand
Function
FENOFIBRATE
Agonist (partial)
Reference
10.1002/ADVS.202306311

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
FENOFIBRATE F108 N-term Van der Waals
FENOFIBRATE F170 2.57x57 TM2 aromatic (edge-to-face)
FENOFIBRATE F170 2.57x57 TM2 hydrophobic
FENOFIBRATE S173 2.60x60 TM2 Van der Waals
FENOFIBRATE F174 2.61x61 TM2 aromatic (edge-to-face)
FENOFIBRATE F174 2.61x61 TM2 hydrophobic
FENOFIBRATE F177 2.64x64 TM2 hydrophobic
FENOFIBRATE F177 2.64x64 TM2 aromatic (edge-to-face)
FENOFIBRATE H178 2.65x65 TM2 Van der Waals
FENOFIBRATE F189 3.25x25 TM3 hydrophobic
FENOFIBRATE L193 3.29x29 TM3 hydrophobic
FENOFIBRATE V196 3.32x32 TM3 hydrophobic
FENOFIBRATE T197 3.33x33 TM3 hydrophobic
FENOFIBRATE F200 3.36x36 TM3 hydrophobic
FENOFIBRATE F268 ECL2 aromatic (edge-to-face)
FENOFIBRATE I271 ECL2 hydrophobic
FENOFIBRATE Y275 5.39x39 TM5 hydrophobic
FENOFIBRATE L276 5.40x40 TM5 hydrophobic
FENOFIBRATE W279 5.43x43 TM5 hydrophobic
FENOFIBRATE W356 6.48x48 TM6 Van der Waals
FENOFIBRATE L359 6.51x51 TM6 hydrophobic
FENOFIBRATE M363 6.55x55 TM6 hydrophobic
FENOFIBRATE S383 7.39x38 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 R S L R C ICL1ECL1 F H R K D ECL1ICL2 P L A Y K R I V ICL2ECL2 W N C E K L Q S V C S D I F P H I ECL2ICL3 T Q K S I I I H T S E D G K V Q V T R ICL3ECL3 K M ECL3N-term M K S I L D G L A D T T F R T I T T D L L Y V G S N D I Q Y E D I K G D M A S K L G Y F P Q K F P L T S F R G S P F Q E K M T A G D N P Q L V P A D Q V N I T E F Y N K S L S S F K E N E E N I Q C G E N F M D I E C F M V L N-termC-term S C E G T A Q P L D N S M G D S D C L H K H A N N A A S V H R A A E S C I K S T V K I A K V T M S V S T D T S A E A L C-term N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R T R P K A V V A F C L M W T I A I V I A V L P L L G D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G P D Q A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D F R S L R H A M F P
Helix box plot — Download: PNG | SVG L N E L V T F T G L T L S L V A I A L Q 1 G S L A V A D L L G S V I F V Y S F I D 2 L F L S G V S A T F S A T V G G L K F L 3 A V V A F C L M W T I A I V I A V L P L 4 Y A Y V I F L L L V S T V G I W F M L Y 5 V L I L V V L I I C W G P L L A I M V Y 6 I P N V T S N L L C L M S C F A F V T 7

GPCRdb(A)
GPCRdb(A)
CB1 receptor
TM2
2x57 2.57x57 F170
2x60 2.60x60 S173
2x61 2.61x61 F174
2x64 2.64x64 F177
2x65 2.65x65 H178
TM3
3x25 3.25x25 F189
3x29 3.29x29 L193
3x32 3.32x32 V196
3x33 3.33x33 T197
3x36 3.36x36 F200
TM5
5x39 5.39x39 Y275
5x40 5.40x40 L276
5x43 5.43x43 W279
TM6
6x48 6.48x48 W356
6x51 6.51x51 L359
6x55 6.55x55 M363
TM7
7x38 7.39x38 S383