PDB
8K9K
Resolution
3.0 Å
Released
May 29, 2024
Receptor
μ
Class
A
Species
Homo sapiens
Ligand
DAMGO
Function
Agonist
Reference
10.1038/S41467-024-47792-6

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Ligand Amino Acid Generic Number Segment Interaction Type
DAMGO I146 3.29x29 TM3 hydrophobic
DAMGO Y150 3.33x33 TM3 hydrophobic
DAMGO M153 3.36x36 TM3 hydrophobic
DAMGO V238 5.42x43 TM5 hydrophobic
DAMGO I298 6.51x51 TM6 hydrophobic
DAMGO V302 6.55x55 TM6 hydrophobic
DAMGO W320 7.35x34 TM7 hydrophobic
DAMGO I324 7.39x38 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM3
3x29 3.29x29 I146
3x33 3.33x33 Y150
3x36 3.36x36 M153
TM5
5x43 5.42x43 V238
TM6
6x51 6.51x51 I298
6x55 6.55x55 V302
TM7
7x34 7.35x34 W320
7x38 7.39x38 I324