Structure information

CCR8

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8KFX

SPECIES

Homo sapiens

RESOLUTION

2.960

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIADV.ADJ7500

PUBLICATION DATE

Feb. 7, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL5268017 Y42 1.39x39 TM1 hydrophobic
CHEMBL5268017 Q91 2.60x60 TM2 polar (hydrogen bond)
CHEMBL5268017 Q91 2.60x60 TM2 Van der Waals
CHEMBL5268017 W99 23.50x50 ECL1 hydrophobic
CHEMBL5268017 V109 3.28x28 TM3 hydrophobic
CHEMBL5268017 V109 3.28x28 TM3 Van der Waals
CHEMBL5268017 S110 3.29x29 TM3 Van der Waals
CHEMBL5268017 Y113 3.32x32 TM3 aromatic (face-to-edge)
CHEMBL5268017 Y113 3.32x32 TM3 Van der Waals
CHEMBL5268017 Y114 3.33x33 TM3 Van der Waals
CHEMBL5268017 Y172 4.64x65 TM4 polar (hydrogen bond)
CHEMBL5268017 Y172 4.64x65 TM4 Van der Waals
CHEMBL5268017 F254 6.51x51 TM6 Van der Waals
CHEMBL5268017 F254 6.51x51 TM6 aromatic (edge-to-face)
CHEMBL5268017 V257 6.54x54 TM6 hydrophobic
CHEMBL5268017 V257 6.54x54 TM6 Van der Waals
CHEMBL5268017 L258 6.55x55 TM6 hydrophobic
CHEMBL5268017 L258 6.55x55 TM6 Van der Waals
CHEMBL5268017 T282 7.35x34 TM7 Van der Waals
CHEMBL5268017 T285 7.38x37 TM7 Van der Waals
CHEMBL5268017 E286 7.39x38 TM7 polar (charge-assisted hydrogen bond)

Ligands

CHEMBL5268017

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Residue Diagrams

S N G L L S F V F L L C Y F V A L L L K 1 L N L A L S D L L F V F S F P F Q T Y Y 2 L T I F F M S S Y F G I Y Y F G S V V K 3 G T T L C L A V W L T A I M A T I P L 4 Y C F M F I T F P I L L G L I N M K F N T 5 L I V V I A S L L F W V P F N V V L F L 6 V P N V C C H T F S I I E T V H T A Y 7
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ICL1 K K L R ICL1ECL1 Q W V F ECL1ICL2 A V Y A L K V R ICL2ECL2 Q V A S E D G V L Q C Y S F Y N Q Q ECL2ICL3 Q N ICL3ECL3 L D ECL3N-term M D Y T L D L S V T T V T D Y Y Y P D I F S S P C D A E L I N-termC-term S C S Q I F N Y L G R Q M P R E S C E K S S S C Q Q H S S R S S S V D Y I L C-term Q T N G K L L L A V F Y C L L F V F S L L G N S L V I L V L V V C S I T D V Y L L N L A L S D L L F V F S F P F Q T Y Y L L D G T V M C K V V S G F Y Y I G F Y S S M F F I T L M S V D R Y L A V V H T I R M G T T L C L A V W L T A I M A T I P L L V F Y T L K W K I F T N F K M N I L G L L I P F T I F M F C Y I K I L H Q L K R C H N K T K A I R L V L I V V I A S L L F W V P F N V V L F L T S L H S M H I G C S I S Q Q L T Y A T H V T E I I S F T H C C V N P V I Y A F V G E K L S E F K K H I F Q K
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Residue Table


GPCRdb(A)
GPCRdb(A)
CCR8
TM1
1x39 1.39x39 Y42
TM2
2x60 2.60x60 Q91
ECL1
23x50 23.50x50 W99
TM3
3x28 3.28x28 V109
3x29 3.29x29 S110
3x32 3.32x32 Y113
3x33 3.33x33 Y114
TM4
4x65 4.64x65 Y172
TM6
6x51 6.51x51 F254
6x54 6.54x54 V257
6x55 6.55x55 L258
TM7
7x34 7.35x34 T282
7x37 7.38x37 T285
7x38 7.39x38 E286