Ligand
Function
Agonist
Reference
| Ligand | Amino Acid | Generic Number | Segment | Interaction Type |
|---|---|---|---|---|
| LysoPS(18:0) | Y37 | 1.35x35 | TM1 | polar (hydrogen bond) |
| LysoPS(18:0) | Y37 | 1.35x35 | TM1 | aromatic (pi-cation) |
| LysoPS(18:0) | Y41 | 1.39x39 | TM1 | Van der Waals |
| LysoPS(18:0) | R90 | 2.60x60 | TM2 | polar (charge-charge) |
| LysoPS(18:0) | R90 | 2.60x60 | TM2 | polar (hydrogen bond) |
| LysoPS(18:0) | Y94 | 2.64x64 | TM2 | Van der Waals |
| LysoPS(18:0) | F110 | 3.29x29 | TM3 | Van der Waals |
| LysoPS(18:0) | K113 | 3.32x32 | TM3 | Van der Waals |
| LysoPS(18:0) | Y114 | 3.33x33 | TM3 | polar (hydrogen bond) |
| LysoPS(18:0) | Y118 | 3.37x37 | TM3 | hydrophobic |
| LysoPS(18:0) | C122 | 3.41x41 | TM3 | Van der Waals |
| LysoPS(18:0) | V159 | 4.52x52 | TM4 | Van der Waals |
| LysoPS(18:0) | V160 | 4.53x53 | TM4 | hydrophobic |
| LysoPS(18:0) | A163 | 4.56x56 | TM4 | hydrophobic |
| LysoPS(18:0) | C164 | 4.57x57 | TM4 | Van der Waals |
| LysoPS(18:0) | P166 | 4.59x59 | TM4 | hydrophobic |
| LysoPS(18:0) | F167 | 4.60x60 | TM4 | hydrophobic |
| LysoPS(18:0) | R171 | ECL2 | polar (hydrogen bond) | |
| LysoPS(18:0) | F182 | 45.51x51 | ECL2 | Van der Waals |
| LysoPS(18:0) | A183 | 45.52x52 | ECL2 | Van der Waals |
| LysoPS(18:0) | M198 | 5.38x39 | TM5 | hydrophobic |
| LysoPS(18:0) | A202 | 5.42x43 | TM5 | hydrophobic |
| LysoPS(18:0) | A205 | 5.45x46 | TM5 | Van der Waals |
| LysoPS(18:0) | Y259 | 6.51x51 | TM6 | Van der Waals |
| LysoPS(18:0) | F263 | 6.55x55 | TM6 | Van der Waals |
| LysoPS(18:0) | Y266 | 6.58x58 | TM6 | Van der Waals |
| LysoPS(18:0) | H287 | 7.35x34 | TM7 | Van der Waals |
| LysoPS(18:0) | L291 | 7.39x38 | TM7 | Van der Waals |
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|
GPCRdb(A)
|
GPCRdb(A)
|
P2RY10
|
|---|---|---|
| TM1 | ||
| 1x35 | 1.35x35 | Y37 |
| 1x39 | 1.39x39 | Y41 |
| TM2 | ||
| 2x60 | 2.60x60 | R90 |
| 2x64 | 2.64x64 | Y94 |
| TM3 | ||
| 3x29 | 3.29x29 | F110 |
| 3x32 | 3.32x32 | K113 |
| 3x33 | 3.33x33 | Y114 |
| 3x37 | 3.37x37 | Y118 |
| 3x41 | 3.41x41 | C122 |
| TM4 | ||
| 4x52 | 4.52x52 | V159 |
| 4x53 | 4.53x53 | V160 |
| 4x56 | 4.56x56 | A163 |
| 4x57 | 4.57x57 | C164 |
| 4x59 | 4.59x59 | P166 |
| 4x60 | 4.60x60 | F167 |
| ECL2 | ||
| 45x51 | 45.51x51 | F182 |
| 45x52 | 45.52x52 | A183 |
| TM5 | ||
| 5x39 | 5.38x39 | M198 |
| 5x43 | 5.42x43 | A202 |
| 5x46 | 5.45x46 | A205 |
| TM6 | ||
| 6x51 | 6.51x51 | Y259 |
| 6x55 | 6.55x55 | F263 |
| 6x58 | 6.58x58 | Y266 |
| TM7 | ||
| 7x34 | 7.35x34 | H287 |
| 7x38 | 7.39x38 | L291 |