Structure information

MC4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8QJ2

SPECIES

Homo sapiens

RESOLUTION

3.400

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

Sept. 25, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
pN162 E100 2.60x60 TM2 polar (charge-assisted hydrogen bond)
pN162 V103 2.63x63 TM2 Van der Waals
pN162 V103 2.63x63 TM2 hydrophobic
pN162 D122 ECL1 Van der Waals
pN162 D126 3.29x29 TM3 polar (charge-assisted hydrogen bond)
pN162 I129 3.32x32 TM3 hydrophobic
pN162 I129 3.32x32 TM3 Van der Waals
pN162 C130 3.33x33 TM3 Van der Waals
pN162 C130 3.33x33 TM3 hydrophobic
pN162 I185 4.61x61 TM4 Van der Waals
pN162 D189 ECL2 Van der Waals
pN162 D189 ECL2 polar (hydrogen bond with backbone)
pN162 I194 5.40x40 TM5 hydrophobic
pN162 I194 5.40x40 TM5 Van der Waals
pN162 F261 6.51x51 TM6 hydrophobic
pN162 F261 6.51x51 TM6 Van der Waals
pN162 H264 6.54x54 TM6 Van der Waals
pN162 L265 6.55x55 TM6 hydrophobic
pN162 L265 6.55x55 TM6 Van der Waals
pN162 Y268 6.58x58 TM6 polar (hydrogen bond)
pN162 Y268 6.58x58 TM6 polar (hydrogen bond)
pN162 Q273 ECL3 Van der Waals
pN162 M281 ECL3 Van der Waals
pN162 F284 7.35x34 TM7 Van der Waals
pN162 F284 7.35x34 TM7 hydrophobic

Ligands

pN162

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Residue Diagrams

I N E L L S I V G L T V F V E P S 1 C S L A V A D M L V S V S N G S E T I V 2 S L L S C I S A L L S S C I V S D I V N 3 V G I I I S C I W A A C T V S G I L F I 4 Y L S A M L A L M T F F M T I L C I I V 5 T I L I G V F V V C W A P F F L H L I F 6 L P D I I S N C M I L I L Y L N F H 7
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ICL1 K N L H ICL1ECL1 N S T D T D A ECL1ICL2 A L Q Y H N I M ICL2ECL2 D ECL2ICL3 P G T G A I R ICL3ECL3 P Q N P Y C V C F M S ECL3N-term M V N S T H R G M H T S L H L W N R S S Y R L H S N A S E S L G K G Y S D G G C Y E Q L F V N-termC-term P L G G L C D L S S R Y C-term S P E V F V T L G V I S L L E N I L V I V A I A K N S P M Y F F I C S L A V A D M L V S V S N G S E T I V I T L L Q S F T V N I D N V I D S V I C S S L L A S I C S L L S I A V D R Y F T I F Y T V K R V G I I I S C I W A A C T V S G I L F I I Y S S S A V I I C L I T M F F T M L A L M A S L Y V H M F L M A R L H I K R I A V L Q G A N M K G A I T L T I L I G V F V V C W A P F F L H L I F Y I S C H F N L Y L I L I M C N S I I D P L I Y A L R S Q E F K E Y L R K T I I C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
MC4 receptor
TM2
2x60 2.60x60 E100
2x63 2.63x63 V103
TM3
3x29 3.29x29 D126
3x32 3.32x32 I129
3x33 3.33x33 C130
TM4
4x61 4.61x61 I185
TM5
5x40 5.40x40 I194
TM6
6x51 6.51x51 F261
6x54 6.54x54 H264
6x55 6.55x55 L265
6x58 6.58x58 Y268
TM7
7x34 7.35x34 F284