PDB
8RQL
Resolution
3.0 Å
Released
Nov. 27, 2024
Receptor
TAS2R14
Class
T2
Species
Homo sapiens
Ligand
flufenamic acid
Function
Agonist
Reference
10.1038/S41467-024-54157-6

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Ligand Amino Acid Generic Number Segment Interaction Type
flufenamic acid S65 2.60x60 TM2 polar (hydrogen bond)
flufenamic acid S65 2.60x60 TM2 Van der Waals
flufenamic acid F76 ECL1 hydrophobic
flufenamic acid F76 ECL1 Van der Waals
flufenamic acid F82 3.25x25 TM3 Van der Waals
flufenamic acid F82 3.25x25 TM3 aromatic (edge-to-face)
flufenamic acid W89 3.32x32 TM3 aromatic (face-to-edge)
flufenamic acid W89 3.32x32 TM3 Van der Waals
flufenamic acid F172 ECL2 hydrophobic
flufenamic acid F172 ECL2 Van der Waals
flufenamic acid I262 7.35x34 TM7 hydrophobic
flufenamic acid I262 7.35x34 TM7 Van der Waals
flufenamic acid S265 7.38x37 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R K I ICL1ECL1 P A L F A ECL1ICL2 N F S N S I F L Y L K W ICL2ECL2 A S I N G Y R R N K T C S S D S S N F T R F S S L ECL2ICL3 K I S G D A S T K A ICL3ECL3 E E ECL3C-term G E P S G H K E F R E S S C-term M G G V I K S I F T F V L I V E F I I G N L G N S F I A L V N C I D W V K G S S V D R I L T A L A I S R I S L V W L I F G S W C V S V F F T E K M F R M L T N I W T V I N H F S V W L A T G L G T F Y F L K I A R V K K V V L V L L L V T S V F L F L N I A L I N I H I N I V L T S T V F I F I P F T L S L A M F L L L I F S M W K H R K K M Q H T V H R G V K S V I T F F L L Y A I F S L S F F I S V W T S E R L N L I I L S Q V M G M A Y P S C H S C V L I L G N K K S L S L R Y L R Q A V L L W M F K D
Helix box plot — Download: PNG | SVG S N G L N G I I F E V I L V F T F I S K 1 T A L A I S R I S L V W L I F G S W C V 2 G T A L W V S F H N I V T W I N T L M R 3 V L V L L L V T S V F L F L N I A L I N 4 F M A L S L T F P I F I F V T S T L V I 5 V I T F F L L Y A I F S L S F F I S V W 6 C S H C S P Y A M G M V Q S L I I L N 7

GPCRdb(A)
GPCRdb(A)
TAS2R14
TM2
2x60 2.60x60 S65
TM3
3x25 3.25x25 F82
3x32 3.32x32 W89
TM7
7x34 7.35x34 I262
7x37 7.38x37 S265