Ligands
Function
Agonist
Agonist
Reference
| Ligand | Amino Acid | Generic Number | Segment | Interaction Type |
|---|---|---|---|---|
| flufenamic acid (R:401) | S65 | 2.60x60 | TM2 | polar (hydrogen bond) |
| flufenamic acid (R:401) | F76 | ECL1 | hydrophobic | |
| flufenamic acid (R:401) | F82 | 3.25x25 | TM3 | hydrophobic |
| flufenamic acid (R:401) | L85 | 3.28x28 | TM3 | Van der Waals |
| flufenamic acid (R:401) | W89 | 3.32x32 | TM3 | aromatic (edge-to-face) |
| flufenamic acid (R:401) | W89 | 3.32x32 | TM3 | hydrophobic |
| flufenamic acid (R:402) | A100 | 3.43x43 | TM3 | Van der Waals |
| flufenamic acid (R:402) | G104 | 3.47x47 | TM3 | Van der Waals |
| flufenamic acid (R:402) | Y107 | 3.50x50 | TM3 | hydrophobic |
| flufenamic acid (R:402) | Y107 | 3.50x50 | TM3 | aromatic (edge-to-face) |
| flufenamic acid (R:402) | I111 | 3.54x54 | TM3 | Van der Waals |
| flufenamic acid (R:401) | F172 | ECL2 | Van der Waals | |
| flufenamic acid (R:401) | S176 | ECL2 | Van der Waals | |
| flufenamic acid (R:402) | S194 | 5.54x54 | TM5 | Van der Waals |
| flufenamic acid (R:402) | M197 | 5.57x57 | TM5 | Van der Waals |
| flufenamic acid (R:402) | F198 | 5.58x58 | TM5 | aromatic (edge-to-face) |
| flufenamic acid (R:402) | F198 | 5.58x58 | TM5 | hydrophobic |
| flufenamic acid (R:402) | L201 | 5.61x61 | TM5 | hydrophobic |
| flufenamic acid (R:402) | I202 | 5.62x62 | TM5 | Van der Waals |
| flufenamic acid (R:402) | V230 | 6.35x35 | TM6 | Van der Waals |
| flufenamic acid (R:402) | V233 | 6.38x38 | TM6 | hydrophobic |
| flufenamic acid (R:402) | F237 | 6.42x42 | TM6 | hydrophobic |
| flufenamic acid (R:401) | I262 | 7.35x34 | TM7 | hydrophobic |
| flufenamic acid (R:401) | S265 | 7.38x37 | TM7 | Van der Waals |
| flufenamic acid (R:402) | H276 | 7.49x49 | TM7 | polar (hydrogen bond) |
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|
GPCRdb(A)
|
GPCRdb(A)
|
TAS2R14
|
|---|---|---|
| TM2 | ||
| 2x60 | 2.60x60 | S65 |
| TM3 | ||
| 3x25 | 3.25x25 | F82 |
| 3x28 | 3.28x28 | L85 |
| 3x32 | 3.32x32 | W89 |
| 3x43 | 3.43x43 | A100 |
| 3x47 | 3.47x47 | G104 |
| 3x50 | 3.50x50 | Y107 |
| 3x54 | 3.54x54 | I111 |
| TM5 | ||
| 5x54 | 5.54x54 | S194 |
| 5x57 | 5.57x57 | M197 |
| 5x58 | 5.58x58 | F198 |
| 5x61 | 5.61x61 | L201 |
| 5x62 | 5.62x62 | I202 |
| TM6 | ||
| 6x35 | 6.35x35 | V230 |
| 6x38 | 6.38x38 | V233 |
| 6x42 | 6.42x42 | F237 |
| TM7 | ||
| 7x34 | 7.35x34 | I262 |
| 7x37 | 7.38x37 | S265 |
| 7x49 | 7.49x49 | H276 |