PDB
8SAI
Resolution
3.3 Å
Released
Oct. 4, 2023
Receptor
GPR34
Class
A
Species
Homo sapiens
Ligand
LysoPS (18:1)
Function
Agonist
Reference
10.1073/PNAS.2308435120

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Ligand Amino Acid Generic Number Segment Interaction Type
LysoPS (18:1) Y135 3.33x33 TM3 Van der Waals
LysoPS (18:1) Y135 3.33x33 TM3 polar (hydrogen bond)
LysoPS (18:1) Y135 3.33x33 TM3 polar (hydrogen bond)
LysoPS (18:1) M136 3.34x34 TM3 hydrophobic
LysoPS (18:1) M136 3.34x34 TM3 Van der Waals
LysoPS (18:1) I140 3.38x38 TM3 Van der Waals
LysoPS (18:1) I143 3.41x41 TM3 hydrophobic
LysoPS (18:1) L181 4.52x52 TM4 Van der Waals
LysoPS (18:1) L181 4.52x52 TM4 hydrophobic
LysoPS (18:1) A182 4.53x53 TM4 Van der Waals
LysoPS (18:1) A182 4.53x53 TM4 hydrophobic
LysoPS (18:1) M189 4.60x60 TM4 Van der Waals
LysoPS (18:1) M189 4.60x60 TM4 hydrophobic
LysoPS (18:1) R208 ECL2 polar (charge-assisted hydrogen bond)
LysoPS (18:1) F219 5.39x39 TM5 Van der Waals
LysoPS (18:1) F219 5.39x39 TM5 hydrophobic
LysoPS (18:1) N220 5.40x40 TM5 polar (hydrogen bond)
LysoPS (18:1) N220 5.40x40 TM5 Van der Waals
LysoPS (18:1) L223 5.43x43 TM5 hydrophobic
LysoPS (18:1) L223 5.43x43 TM5 Van der Waals
LysoPS (18:1) R286 6.55x55 TM6 polar (charge-assisted hydrogen bond)
LysoPS (18:1) Y289 6.58x58 TM6 polar (hydrogen bond)
LysoPS (18:1) Q293 ECL3 polar (hydrogen bond)
LysoPS (18:1) Q293 ECL3 Van der Waals
LysoPS (18:1) N309 7.35x34 TM7 polar (hydrogen bond)
LysoPS (18:1) N309 7.35x34 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R K R ICL1ECL1 N K W T L ECL1ICL2 I Q Q R K A I T T ICL2ECL2 G H N S T M C F H Y R D K H N A ECL2ICL3 R R S K F P N ICL3ECL3 Q L N V S ECL3N-term M R S H T I T M T T T S V S S W P Y S S H R M R F I T N H S D Q P P Q N F S A T P N V T T C P M D E K N-termC-term G E P S R S E S T S E F K P G Y S L H D T S V A V K I Q S S S K S T C-term L L S T V L T T S Y S V I F I V G L V G N I I A L Y V F L G I H N S I Q I Y L L N V A I A D L L L I F C L P F R I M Y H I N Q G V I L C K V V G T L F Y M N M Y I S I I L L G F I S L D R Y I K I N R S K Q S I Y V C C I V W M L A L G G F L T M I I L T L K K G K G E A I F N F I L V V M F W L I F L L I I L S Y I K I G K N L L R I S K S G K Y A T T A R N S F I V L I I F T I C F V P Y H A F R F I Y I S S S C Y W K E I V H K T N E I M L V L S S F N S C L D P V M Y F L M S S N M C Q R F Q I R K I L L F R
Helix box plot — Download: PNG | SVG I N G V L G V I F I V S Y S T T L V T S 1 L N V A I A D L L L I F C L P F R I M Y 2 F G L L I I S I Y M N M Y F L T G V V K 3 S I Y V C C I V W M L A L G G F L T M I 4 Y S L I I L L F I L W F M V V L I F N F 5 S F I V L I I F I T C F V P Y H A F R F I 6 V P D L C S N F S S L V L M I E N T K 7

GPCRdb(A)
GPCRdb(A)
GPR34
TM3
3x33 3.33x33 Y135
3x34 3.34x34 M136
3x38 3.38x38 I140
3x41 3.41x41 I143
TM4
4x52 4.52x52 L181
4x53 4.53x53 A182
4x60 4.60x60 M189
TM5
5x39 5.39x39 F219
5x40 5.40x40 N220
5x43 5.43x43 L223
TM6
6x55 6.55x55 R286
6x58 6.58x58 Y289
TM7
7x34 7.35x34 N309