PDB
8SMV
Resolution
2.7 Å
Released
Feb. 21, 2024
Receptor
GPR161
Class
A
Species
Homo sapiens
Ligand
Function
Cholesterol
Allosteric agonist
Reference
10.1101/2023.05.23.540554

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Ligand Amino Acid Generic Number Segment Interaction Type
Cholesterol V274 6.39x39 TM6 Van der Waals
Cholesterol G277 6.42x42 TM6 Van der Waals
Cholesterol A278 6.43x43 TM6 Van der Waals
Cholesterol L322 7.51x51 TM7 Van der Waals
Cholesterol L326 7.55x55 TM7 hydrophobic
Cholesterol W327 7.56x56 TM7 Van der Waals
Cholesterol R332 8.51x51 H8 Van der Waals

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ICL1 S Y L L ICL1ECL1 E W I F ECL1ICL2 P M V Y P M K I ICL2ECL2 W S S V E F D E F K W M C V A A W H R ECL2ICL3 V V I V E E D A Q R T G R K N S S T S T S S S G S R R N A F Q G ICL3ECL3 G K S S V ECL3N-term M S L N S S L S C R K E L S N L T E E E G G N-termC-term F G D R Y Y R E P F V Q R Q R T S R L F S I S N R I T D L G L S P H L T A L M A G G Q P L G H S S S T G D T G F S C S Q D S G T D M M L L E D Y T S D D N P P S H C T C P P K R R S S V T F E D E V E Q I K E A A K N S I L H V K A E V H K S L D S Y A A S L A K A I E A E A K I N L F G E E A L P G V L V T A R T V P G G G F G G R R G S R T L V S Q R L Q L Q S I E E G D V L A A E Q R C-term E G G V I I T Q F I A I I V I T I F V C L G N L V I V V T L Y K K T L S N K F V F S L T L S N F L L S V L V L P F V V T S S I R R G V V W C N F S A L L Y L L I S S A S M L T L G V I A I D R Y Y A V L Y T G N R A V M A L V Y I W L H S L I G C L P P L F G E P G Y T A F W Q I W C A L F P F L V M L V C Y G F I F R V A R V K A R K V H C G T V V Y S A N Q C K A L I T I L V V L G A F M V T W G P Y M V V I A S E A L W S P S L E T W A T W L S F A S A V C H P L I Y G L W N K T L L G V R K E M C
Helix box plot — Download: PNG | SVG L N G L C V F I T I V I I A I F Q T I I 1 F S L T L S N F L L S L V V L P F V V T S 2 V G L T L M S A S S I L L Y L L A S F N 3 A V M A L V Y I W L H S L I G C L P P L 4 Y C V L M V L F P F L A C W I Q W F A T Y 5 L V V L G A F M V T W G P Y M V V I A S 6 L P H C V A S A F S L W T A W T E L S 7

GPCRdb(A)
GPCRdb(A)
GPR161
TM6
6x39 6.39x39 V274
6x42 6.42x42 G277
6x43 6.43x43 A278
TM7
7x51 7.51x51 L322
7x55 7.55x55 L326
7x56 7.56x56 W327
H8
8x51 8.51x51 R332