PDB
8SMV
Resolution
2.7 Å
Released
Feb. 21, 2024
Receptor
GPR161
Class
A
Species
Homo sapiens
Ligand
Cholesterol
Function
Allosteric agonist
Reference
10.1101/2023.05.23.540554

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Ligand Amino Acid Generic Number Segment Interaction Type
Cholesterol A278 6.43x43 TM6 hydrophobic
Cholesterol L326 7.55x55 TM7 hydrophobic
Cholesterol W327 7.56x56 TM7 hydrophobic

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ICL1 S Y L L ICL1ECL1 E W I F ECL1ICL2 P M V Y P M K I ICL2ECL2 W S S V E F D E F K W M C V A A W H R ECL2ICL3 V V I V E E D A Q R T G R K N S S T S T S S S G S R R N A F Q G ICL3ECL3 G K S S V ECL3N-term M S L N S S L S C R K E L S N L T E E E G G N-termC-term F G D R Y Y R E P F V Q R Q R T S R L F S I S N R I T D L G L S P H L T A L M A G G Q P L G H S S S T G D T G F S C S Q D S G T D M M L L E D Y T S D D N P P S H C T C P P K R R S S V T F E D E V E Q I K E A A K N S I L H V K A E V H K S L D S Y A A S L A K A I E A E A K I N L F G E E A L P G V L V T A R T V P G G G F G G R R G S R T L V S Q R L Q L Q S I E E G D V L A A E Q R C-term E G G V I I T Q F I A I I V I T I F V C L G N L V I V V T L Y K K T L S N K F V F S L T L S N F L L S V L V L P F V V T S S I R R G V V W C N F S A L L Y L L I S S A S M L T L G V I A I D R Y Y A V L Y T G N R A V M A L V Y I W L H S L I G C L P P L F G E P G Y T A F W Q I W C A L F P F L V M L V C Y G F I F R V A R V K A R K V H C G T V V Y S A N Q C K A L I T I L V V L G A F M V T W G P Y M V V I A S E A L W S P S L E T W A T W L S F A S A V C H P L I Y G L W N K T L L G V R K E M C
Helix box plot — Download: PNG | SVG L N G L C V F I T I V I I A I F Q T I I 1 F S L T L S N F L L S L V V L P F V V T S 2 V G L T L M S A S S I L L Y L L A S F N 3 A V M A L V Y I W L H S L I G C L P P L 4 Y C V L M V L F P F L A C W I Q W F A T Y 5 L V V L G A F M V T W G P Y M V V I A S 6 L P H C V A S A F S L W T A W T E L S 7

GPCRdb(A)
GPCRdb(A)
GPR161
TM6
6x43 6.43x43 A278
TM7
7x55 7.55x55 L326
7x56 7.56x56 W327