PDB
8T1V
Resolution
2.6 Å
Released
Dec. 4, 2024
Receptor
GPR6
Class
A
Species
Homo sapiens
Ligand
Function
CHEMBL4763822
Inverse agonist
Reference
10.1126/SCISIGNAL.ADO8741

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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL4763822 D76 1.36x36 TM1 Van der Waals
CHEMBL4763822 L79 1.39x39 TM1 hydrophobic
CHEMBL4763822 A121 2.53x53 TM2 hydrophobic
CHEMBL4763822 H128 2.60x60 TM2 aromatic (edge-to-face)
CHEMBL4763822 Q132 2.64x64 TM2 Van der Waals
CHEMBL4763822 V145 3.29x29 TM3 Van der Waals
CHEMBL4763822 L148 3.32x32 TM3 hydrophobic
CHEMBL4763822 V149 3.33x33 TM3 Van der Waals
CHEMBL4763822 F152 3.36x36 TM3 hydrophobic
CHEMBL4763822 V219 ECL2 Van der Waals
CHEMBL4763822 L222 ECL2 Van der Waals
CHEMBL4763822 V227 5.40x40 TM5 Van der Waals
CHEMBL4763822 L230 5.43x43 TM5 hydrophobic
CHEMBL4763822 S231 5.44x44 TM5 Van der Waals
CHEMBL4763822 W292 6.48x48 TM6 hydrophobic
CHEMBL4763822 F295 6.51x51 TM6 hydrophobic
CHEMBL4763822 F295 6.51x51 TM6 aromatic (edge-to-face)
CHEMBL4763822 A296 6.52x52 TM6 Van der Waals
CHEMBL4763822 C299 6.55x55 TM6 Van der Waals
CHEMBL4763822 L315 7.39x38 TM7 hydrophobic
CHEMBL4763822 A318 7.42x41 TM7 hydrophobic
CHEMBL4763822 T319 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 P A L R ICL1ECL1 L V P ECL1ICL2 A L T Y Y ICL2ECL2 W N C L A E R A A C S V V R P L ECL2ICL3 L Q Q H C ICL3ECL3 S H E D P ECL3N-term M N A S A A S L N D S Q V V V V A A E G A A A A A T A A G G P D T G E W G P P A A A A L G A G G G A N G S L E L S S Q L S A G P P G L L L P N-termC-term G C F Q S K V P F R S R S P S E V C-term A V N P W D V L L C V S G T V I A G E N A L V V A L I A S T T P M F V L V G S L A T A D L L A G C G L I L H F V F Q Y S E T V S L L T V G F L V A S F A A S V S S L L A I T V D R Y L S L Y N S R R T L L G V H L L L A A T W T V S L G L G L L P V L G A R S H V A L L S A A F F M V F G I M L H L Y V R I C Q V V W R H A H Q I A L A P P H L A A T R K G V G T L A V V L G T F G A S W L P F A I Y C V V G A V Y T Y A T L L P A T Y N S M I N P I I Y A F R N Q E L W L I Q R A L L C
Helix box plot — Download: PNG | SVG A N E G A I V T G S V C L L V D W P N V 1 G S L A T A D L L A G C G L I L H F V F 2 A L L S S V S A A F S A V L F G V T L L 3 V H L L L A A T W T V S L G L G L L P V 4 Y L H L M I G F V M F F A A S L L A V H 5 A V V L G T F G A S W L P F A I Y C V V 6 I P N I M S N Y T A P L L T A Y T Y V 7

GPCRdb(A)
GPCRdb(A)
GPR6
TM1
1x36 1.36x36 D76
1x39 1.39x39 L79
TM2
2x53 2.53x53 A121
2x60 2.60x60 H128
2x64 2.64x64 Q132
TM3
3x29 3.29x29 V145
3x32 3.32x32 L148
3x33 3.33x33 V149
3x36 3.36x36 F152
TM5
5x40 5.40x40 V227
5x43 5.43x43 L230
5x44 5.44x44 S231
TM6
6x48 6.48x48 W292
6x51 6.51x51 F295
6x52 6.52x52 A296
6x55 6.55x55 C299
TM7
7x38 7.39x38 L315
7x41 7.42x41 A318
7x42 7.43x42 T319