PDB
8T1W
Resolution
3.5 Å
Released
Dec. 4, 2024
Receptor
GPR6
Class
A
Species
Homo sapiens
Ligand
solengepras
Function
Inverse agonist
Reference
10.1126/SCISIGNAL.ADO8741

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Ligand Amino Acid Generic Number Segment Interaction Type
solengepras H128 2.60x60 TM2 polar (hydrogen bond)
solengepras V145 3.29x29 TM3 Van der Waals
solengepras V145 3.29x29 TM3 hydrophobic
solengepras L148 3.32x32 TM3 hydrophobic
solengepras L148 3.32x32 TM3 Van der Waals
solengepras V149 3.33x33 TM3 Van der Waals
solengepras V149 3.33x33 TM3 hydrophobic
solengepras F152 3.36x36 TM3 Van der Waals
solengepras F152 3.36x36 TM3 aromatic (face-to-face)
solengepras V219 ECL2 hydrophobic
solengepras V219 ECL2 Van der Waals
solengepras L222 ECL2 Van der Waals
solengepras V227 5.40x40 TM5 Van der Waals
solengepras V227 5.40x40 TM5 hydrophobic
solengepras L230 5.43x43 TM5 hydrophobic
solengepras L230 5.43x43 TM5 Van der Waals
solengepras S231 5.44x44 TM5 Van der Waals
solengepras S231 5.44x44 TM5 polar (hydrogen bond)
solengepras W292 6.48x48 TM6 Van der Waals
solengepras W292 6.48x48 TM6 hydrophobic
solengepras F295 6.51x51 TM6 aromatic (edge-to-face)
solengepras F295 6.51x51 TM6 Van der Waals
solengepras A296 6.52x52 TM6 Van der Waals
solengepras A296 6.52x52 TM6 polar (hydrogen bond with backbone)
solengepras C299 6.55x55 TM6 Van der Waals
solengepras L315 7.39x38 TM7 hydrophobic
solengepras L315 7.39x38 TM7 Van der Waals
solengepras T319 7.43x42 TM7 polar (hydrogen bond)
solengepras T319 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 P A L R ICL1ECL1 L V P ECL1ICL2 A L T Y Y ICL2ECL2 W N C L A E R A A C S V V R P L ECL2ICL3 L Q Q H C ICL3ECL3 S H E D P ECL3N-term M N A S A A S L N D S Q V V V V A A E G A A A A A T A A G G P D T G E W G P P A A A A L G A G G G A N G S L E L S S Q L S A G P P G L L L P N-termC-term G C F Q S K V P F R S R S P S E V C-term A V N P W D V L L C V S G T V I A G E N A L V V A L I A S T T P M F V L V G S L A T A D L L A G C G L I L H F V F Q Y S E T V S L L T V G F L V A S F A A S V S S L L A I T V D R Y L S L Y N S R R T L L G V H L L L A A T W T V S L G L G L L P V L G A R S H V A L L S A A F F M V F G I M L H L Y V R I C Q V V W R H A H Q I A L A P P H L A A T R K G V G T L A V V L G T F G A S W L P F A I Y C V V G A V Y T Y A T L L P A T Y N S M I N P I I Y A F R N Q E L W L I Q R A L L C
Helix box plot — Download: PNG | SVG A N E G A I V T G S V C L L V D W P N V 1 G S L A T A D L L A G C G L I L H F V F 2 A L L S S V S A A F S A V L F G V T L L 3 V H L L L A A T W T V S L G L G L L P V 4 Y L H L M I G F V M F F A A S L L A V H 5 A V V L G T F G A S W L P F A I Y C V V 6 I P N I M S N Y T A P L L T A Y T Y V 7

GPCRdb(A)
GPCRdb(A)
GPR6
TM2
2x60 2.60x60 H128
TM3
3x29 3.29x29 V145
3x32 3.32x32 L148
3x33 3.33x33 V149
3x36 3.36x36 F152
TM5
5x40 5.40x40 V227
5x43 5.43x43 L230
5x44 5.44x44 S231
TM6
6x48 6.48x48 W292
6x51 6.51x51 F295
6x52 6.52x52 A296
6x55 6.55x55 C299
TM7
7x38 7.39x38 L315
7x42 7.43x42 T319