PDB
8T3S
Resolution
3.1 Å
Released
Jan. 24, 2024
Receptor
FFA2
Class
A
Species
Homo sapiens
Ligand
butyric acid
Function
Agonist
Reference
10.1126/SCIADV.ADJ2384

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Ligand Amino Acid Generic Number Segment Interaction Type
butyric acid Y90 3.33x33 TM3 hydrophobic
butyric acid V144 4.60x60 TM4 hydrophobic
butyric acid R180 5.39x40 TM5 polar (charge-assisted hydrogen bond)
butyric acid L183 5.42x43 TM5 hydrophobic
butyric acid L183 5.42x43 TM5 Van der Waals
butyric acid Y238 6.51x51 TM6 polar (hydrogen bond)
butyric acid Y238 6.51x51 TM6 Van der Waals
butyric acid H242 6.55x55 TM6 polar (hydrogen bond)
butyric acid H242 6.55x55 TM6 Van der Waals
butyric acid R255 7.35x34 TM7 polar (charge-assisted hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 P Q P ICL1ECL1 N F R W Y L ECL1ICL2 P V Q Y K L S R ICL2ECL2 T E Q V R S G N E I T C Y E N F T D N ECL2ICL3 P L V ICL3ECL3 K S P W ECL3N-term M L N-termC-term R N Q G S S L L G R R G K D T A E G T N E D R G V G Q G E G M P S S D F T T E C-term P D W K S S L I L M A Y I I I F L T G L P A N L L A L R A F V G R I R Q A P V H I L L L S L T L A D L L L L L L L P F K I I E A A S P K V V C A L T S F G F Y S S I Y C S T W L L A G I S I E R Y L G V A F R P L Y G V I A A L V A W V M S F G H C T I V I I V Q Y L N T Q L D V V L P V R L E L C L V L F F I P M A V T I F C Y W R F V W I M L S Q G A Q R R R R A V G L A V V T L L N F L V C F G P Y N V S H L V G Y H Q R W R S I A V V F S S L N A S L D P L L F Y F S S S V F G R L V R R A G L Q V
Helix box plot — Download: PNG | SVG L N A P L G T L F I I I Y A M L I L S S 1 L S L T L A D L L L L L L L P F K I I E 2 G A L L W T S C Y I S S Y F G F S T L A 3 G V I A A L V A W V M S F G H C T I V I 4 Y C F I T V A M P I F F L V L C L E L R V 5 A V V T L L N F V L C F G P Y N V S H L V 6 L P D L S A N L S S F V V A I S R W 7

GPCRdb(A)
GPCRdb(A)
FFA2 receptor
TM3
3x33 3.33x33 Y90
TM4
4x60 4.60x60 V144
TM5
5x40 5.39x40 R180
5x43 5.42x43 L183
TM6
6x51 6.51x51 Y238
6x55 6.55x55 H242
TM7
7x34 7.35x34 R255