PDB
8T3V
Resolution
3.4 Å
Released
Jan. 24, 2024
Receptor
FFA1
Class
A
Species
Homo sapiens
Ligand
Function
docosahexaenoic acid
Agonist
Reference
10.1126/SCIADV.ADJ2384

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Ligand Amino Acid Generic Number Segment Interaction Type
docosahexaenoic acid L54 2.52x52 TM2 hydrophobic
docosahexaenoic acid A83 3.29x29 TM3 hydrophobic
docosahexaenoic acid V84 3.30x30 TM3 hydrophobic
docosahexaenoic acid A85 3.31x31 TM3 hydrophobic
docosahexaenoic acid F87 3.33x33 TM3 hydrophobic
docosahexaenoic acid Y91 3.37x37 TM3 Van der Waals
docosahexaenoic acid L135 4.54x54 TM4 hydrophobic
docosahexaenoic acid L138 4.57x57 TM4 hydrophobic
docosahexaenoic acid G139 4.58x58 TM4 Van der Waals
docosahexaenoic acid F142 4.61x61 TM4 hydrophobic
docosahexaenoic acid L171 45.51x51 ECL2 Van der Waals
docosahexaenoic acid W174 ECL2 hydrophobic
docosahexaenoic acid R183 5.39x40 TM5 polar (hydrogen bond)
docosahexaenoic acid R183 5.39x40 TM5 polar (charge-charge)
docosahexaenoic acid R183 5.39x40 TM5 hydrophobic
docosahexaenoic acid Y240 6.51x51 TM6 Van der Waals
docosahexaenoic acid N244 6.55x55 TM6 Van der Waals
docosahexaenoic acid R258 7.35x34 TM7 polar (charge-charge)
docosahexaenoic acid R258 7.35x34 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 L ICL1ECL1 G A W P L ECL1ICL2 P L G Y Q A F R ICL2ECL2 P G G W L D H S N T S L G I N T P V N G S P V C L E A W ECL2ICL3 S G L T H ICL3ECL3 P N L G ECL3N-term M D L N-termC-term G G K S Q K C-term P P Q L S F G L Y V A A F A L G F P L N V L A I R G A T A H A R L R T P S L V Y A L N L G C S D L L L T V S L P L K A V E A L A S P A S L C P V F A V A H F F P L Y A G G G F L A A L S A G R Y L G A A F R P C Y S W G V C A A I W A L V L C H L G L V F G L E A D P A S A G P A R F S L S L L L F F L P L A I T A F C Y V G C L R A L A R R R K L R A A W V A G G A L L T L L L C V G P Y N A S N V A S F L Y G S W R K L G L I T G A W S V V L N P L V T G Y L G R G T V C Q P G L K A A R T
Helix box plot — Download: PNG | SVG V N L P F G L A F A A V Y L G F S L Q P 1 L N L G C S D L L L T V S L P L K A V E 2 A A L F G G G A Y L P F F H A V A F V P 3 S W G V C A A I W A L V L C H L G L V F 4 Y C F A T I A L P L F F L L L S L S F R A 5 A G G A L L T L L L C V G P Y N A S N V A 6 L P N L V V S W A G T I L G L K R W S 7

GPCRdb(A)
GPCRdb(A)
FFA1 receptor
TM2
2x52 2.52x52 L54
TM3
3x29 3.29x29 A83
3x30 3.30x30 V84
3x31 3.31x31 A85
3x33 3.33x33 F87
3x37 3.37x37 Y91
TM4
4x54 4.54x54 L135
4x57 4.57x57 L138
4x58 4.58x58 G139
4x61 4.61x61 F142
ECL2
45x51 45.51x51 L171
TM5
5x40 5.39x40 R183
TM6
6x51 6.51x51 Y240
6x55 6.55x55 N244
TM7
7x34 7.35x34 R258