PDB
8TB7
Resolution
2.9 Å
Released
Oct. 4, 2023
Receptor
GPR61
Class
A
Species
Homo sapiens
Ligand
Function
compound 1 [PMID: 37741852]
Inverse agonist
Reference
10.1038/S41467-023-41646-3

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Ligand Amino Acid Generic Number Segment Interaction Type
compound 1 [PMID: 37741852] N146 3.47x47 TM3 polar (hydrogen bond)
compound 1 [PMID: 37741852] R149 3.50x50 TM3 polar (hydrogen bond)
compound 1 [PMID: 37741852] I233 5.54x54 TM5 Van der Waals
compound 1 [PMID: 37741852] V236 ICL3 Van der Waals
compound 1 [PMID: 37741852] Y237 ICL3 Van der Waals
compound 1 [PMID: 37741852] M240 ICL3 Van der Waals
compound 1 [PMID: 37741852] V368 6.35x35 TM6 hydrophobic
compound 1 [PMID: 37741852] V369 6.36x36 TM6 hydrophobic
compound 1 [PMID: 37741852] L370 6.37x37 TM6 Van der Waals
compound 1 [PMID: 37741852] A372 6.39x39 TM6 hydrophobic
compound 1 [PMID: 37741852] V373 6.40x40 TM6 hydrophobic
compound 1 [PMID: 37741852] F421 7.52x52 TM7 Van der Waals
compound 1 [PMID: 37741852] Y422 7.53x53 TM7 Van der Waals
compound 1 [PMID: 37741852] L425 ICL4 hydrophobic
compound 1 [PMID: 37741852] N426 8.47x47 H8 polar (hydrogen bond)
compound 1 [PMID: 37741852] R427 8.48x48 H8 Van der Waals

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ICL1 P A L R ICL1ECL1 F D H A L ECL1ICL2 P M R Y E V R M ICL2ECL2 E G A P S V P P G C S L Q W S H ECL2ICL3 T W M E T P R Q R S E S L S S R S T M V T S S G A P Q T T ICL3ECL3 A Q P I S ECL3N-term M E S S P I P Q S S G N S S T L G R V P Q T P G P S T A S G V P E V G N-termC-term C F F K P A P E E E L R L P S R E G S I E E N F L Q F L Q G T G C P S E S W V S R P L P S P K Q E P P A V D F R I P G Q I A E E T S E F L E Q Q L T S D I I M S D S Y L R P A A S P R L E S C-term L R D V A S E S V A L F F M L L L D L T A V A G N A A V M A V I A K T K F V F V F H L C L V D L L A A L T L M P L A M L S S S A L F G E V A C R L Y L F L S V C F V S L A I L S V S A I N V E R Y Y Y V V H T L G L V A S V L V G V W V K A L A M A S V P V L G R V S W E S A Y C Q L F V V V F A V L Y F L L P L L L I L V V Y C S M F R V A R V A A M Q H G P L P P H R T F G G G K A A V V L L A V G G Q F L L C W L P Y F S F H L Y V A L S T G Q V E S V V T W I G Y F C F T S N P F F Y G C L N R Q L S K I R G E Q F V
Helix box plot — Download: PNG | SVG A N G A V A T L D L L L M F F L A V S E 1 F H L C L V D L L A A T L L M P L A M L S 2 A S V S L I A L S V F C V S L F L Y L R 3 V A S V L V G V W V K A L A M A S V P V 4 Y V V L I L L L P L L F Y L V A F V V V F 5 L A V G G Q F L L C W L P Y F S F H L Y 6 F P N S T F C F Y G I W T V V S E V Q 7

GPCRdb(A)
GPCRdb(A)
GPR61
TM3
3x47 3.47x47 N137
3x50 3.50x50 R140
TM5
5x54 5.54x54 I224
TM6
6x35 6.35x35 V287
6x36 6.36x36 V288
6x37 6.37x37 L289
6x39 6.39x39 A291
6x40 6.40x40 V292
TM7
7x52 7.52x52 F340
7x53 7.53x53 Y341
H8
8x47 8.47x47 N345
8x48 8.48x48 R346