PDB
8TF5
Resolution
2.1 Å
Released
Dec. 4, 2024
Receptor
GPR6
Class
A
Species
Homo sapiens
Ligands
Function
oleic acid (A:1210)
Agonist
oleic acid (A:1213)
Agonist
Reference
10.1126/SCISIGNAL.ADO8741
oleic acid (A:1210) oleic acid (A:1213)

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Ligand Amino Acid Generic Number Segment Interaction Type
oleic acid (A:1210) H128 2.60x60 TM2 Van der Waals
oleic acid (A:1210) V145 3.29x29 TM3 Van der Waals
oleic acid (A:1210) L148 3.32x32 TM3 hydrophobic
oleic acid (A:1210) V149 3.33x33 TM3 hydrophobic
oleic acid (A:1213) F152 3.36x36 TM3 Van der Waals
oleic acid (A:1210) F152 3.36x36 TM3 hydrophobic
oleic acid (A:1213) A153 3.37x37 TM3 Van der Waals
oleic acid (A:1213) V156 3.40x40 TM3 hydrophobic
oleic acid (A:1213) S157 3.41x41 TM3 Van der Waals
oleic acid (A:1213) A191 4.48x48 TM4 Van der Waals
oleic acid (A:1213) T192 4.49x49 TM4 hydrophobic
oleic acid (A:1213) V195 4.52x52 TM4 hydrophobic
oleic acid (A:1213) S196 4.53x53 TM4 Van der Waals
oleic acid (A:1213) L199 4.56x56 TM4 Van der Waals
oleic acid (A:1210) V218 ECL2 Van der Waals
oleic acid (A:1210) V219 ECL2 hydrophobic
oleic acid (A:1210) R220 ECL2 polar (charge-charge)
oleic acid (A:1210) R220 ECL2 polar (hydrogen bond with backbone)
oleic acid (A:1210) L222 ECL2 Van der Waals
oleic acid (A:1210) V227 5.40x40 TM5 hydrophobic
oleic acid (A:1213) L230 5.43x43 TM5 Van der Waals
oleic acid (A:1210) L230 5.43x43 TM5 hydrophobic
oleic acid (A:1210) S231 5.44x44 TM5 Van der Waals
oleic acid (A:1213) A233 5.46x46 TM5 hydrophobic
oleic acid (A:1210) F234 5.47x47 TM5 hydrophobic
oleic acid (A:1213) F234 5.47x47 TM5 hydrophobic
oleic acid (A:1213) V237 5.50x50 TM5 Van der Waals
oleic acid (A:1213) W292 6.48x48 TM6 Van der Waals
oleic acid (A:1210) W292 6.48x48 TM6 hydrophobic
oleic acid (A:1210) F295 6.51x51 TM6 hydrophobic
oleic acid (A:1210) A296 6.52x52 TM6 Van der Waals
oleic acid (A:1210) C299 6.55x55 TM6 hydrophobic
oleic acid (A:1210) A308 7.32x31 TM7 Van der Waals
oleic acid (A:1210) T311 7.35x34 TM7 hydrophobic
oleic acid (A:1210) Y312 7.36x35 TM7 hydrophobic
oleic acid (A:1210) L315 7.39x38 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 P A L R ICL1ECL1 L V P ECL1ICL2 A L T Y Y ICL2ECL2 W N C L A E R A A C S V V R P L ECL2ICL3 L Q Q H C ICL3ECL3 S H E D P ECL3N-term M N A S A A S L N D S Q V V V V A A E G A A A A A T A A G G P D T G E W G P P A A A A L G A G G G A N G S L E L S S Q L S A G P P G L L L P N-termC-term G C F Q S K V P F R S R S P S E V C-term A V N P W D V L L C V S G T V I A G E N A L V V A L I A S T T P M F V L V G S L A T A D L L A G C G L I L H F V F Q Y S E T V S L L T V G F L V A S F A A S V S S L L A I T V D R Y L S L Y N S R R T L L G V H L L L A A T W T V S L G L G L L P V L G A R S H V A L L S A A F F M V F G I M L H L Y V R I C Q V V W R H A H Q I A L A P P H L A A T R K G V G T L A V V L G T F G A S W L P F A I Y C V V G A V Y T Y A T L L P A T Y N S M I N P I I Y A F R N Q E L W L I Q R A L L C
Helix box plot — Download: PNG | SVG A N E G A I V T G S V C L L V D W P N V 1 G S L A T A D L L A G C G L I L H F V F 2 A L L S S V S A A F S A V L F G V T L L 3 V H L L L A A T W T V S L G L G L L P V 4 Y L H L M I G F V M F F A A S L L A V H 5 A V V L G T F G A S W L P F A I Y C V V 6 I P N I M S N Y T A P L L T A Y T Y V 7

GPCRdb(A)
GPCRdb(A)
GPR6
TM2
2x60 2.60x60 H128
TM3
3x29 3.29x29 V145
3x32 3.32x32 L148
3x33 3.33x33 V149
3x36 3.36x36 F152
3x37 3.37x37 A153
3x40 3.40x40 V156
3x41 3.41x41 S157
TM4
4x48 4.48x48 A191
4x49 4.49x49 T192
4x52 4.52x52 V195
4x53 4.53x53 S196
4x56 4.56x56 L199
TM5
5x40 5.40x40 V227
5x43 5.43x43 L230
5x44 5.44x44 S231
5x46 5.46x46 A233
5x47 5.47x47 F234
5x50 5.50x50 V237
TM6
6x48 6.48x48 W292
6x51 6.51x51 F295
6x52 6.52x52 A296
6x55 6.55x55 C299
TM7
7x31 7.32x31 A308
7x34 7.35x34 T311
7x35 7.36x35 Y312
7x38 7.39x38 L315