PDB
8TF5
Resolution
2.1 Å
Released
Dec. 4, 2024
Receptor
GPR6
Class
A
Species
Homo sapiens
Ligand
oleic acid
Function
Agonist
Reference
10.1126/SCISIGNAL.ADO8741

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Ligand Amino Acid Generic Number Segment Interaction Type
oleic acid A228 5.41x41 TM5 hydrophobic
oleic acid A232 5.45x45 TM5 hydrophobic
oleic acid F235 5.48x48 TM5 hydrophobic
oleic acid M236 5.49x49 TM5 hydrophobic
oleic acid V300 6.56x56 TM6 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 P A L R ICL1ECL1 L V P ECL1ICL2 A L T Y Y ICL2ECL2 W N C L A E R A A C S V V R P L ECL2ICL3 L Q Q H C ICL3ECL3 S H E D P ECL3N-term M N A S A A S L N D S Q V V V V A A E G A A A A A T A A G G P D T G E W G P P A A A A L G A G G G A N G S L E L S S Q L S A G P P G L L L P N-termC-term G C F Q S K V P F R S R S P S E V C-term A V N P W D V L L C V S G T V I A G E N A L V V A L I A S T T P M F V L V G S L A T A D L L A G C G L I L H F V F Q Y S E T V S L L T V G F L V A S F A A S V S S L L A I T V D R Y L S L Y N S R R T L L G V H L L L A A T W T V S L G L G L L P V L G A R S H V A L L S A A F F M V F G I M L H L Y V R I C Q V V W R H A H Q I A L A P P H L A A T R K G V G T L A V V L G T F G A S W L P F A I Y C V V G A V Y T Y A T L L P A T Y N S M I N P I I Y A F R N Q E L W L I Q R A L L C
Helix box plot — Download: PNG | SVG A N E G A I V T G S V C L L V D W P N V 1 G S L A T A D L L A G C G L I L H F V F 2 A L L S S V S A A F S A V L F G V T L L 3 V H L L L A A T W T V S L G L G L L P V 4 Y L H L M I G F V M F F A A S L L A V H 5 A V V L G T F G A S W L P F A I Y C V V 6 I P N I M S N Y T A P L L T A Y T Y V 7

GPCRdb(A)
GPCRdb(A)
GPR6
TM5
5x41 5.41x41 A228
5x45 5.45x45 A232
5x48 5.48x48 F235
5x49 5.49x49 M236
TM6
6x56 6.56x56 V300