Structure information

CXCR4

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8U4O

SPECIES

Homo sapiens

RESOLUTION

3.290

PREFERRED CHAIN

R

REFERENCE

10.1038/S41594-024-01397-1

PUBLICATION DATE

March 13, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CXC12 P27 N-term hydrophobic
CXC12 W94 2.60x60 TM2 hydrophobic
CXC12 Y116 3.32x32 TM3 hydrophobic
CXC12 C186 45.50x50 ECL2 Van der Waals
CXC12 C186 45.50x50 ECL2 polar (hydrogen bond with backbone)
CXC12 D187 45.51x51 ECL2 polar (charge-assisted hydrogen bond)
CXC12 F189 ECL2 Van der Waals
CXC12 F189 ECL2 hydrophobic
CXC12 D193 ECL2 polar (charge-assisted hydrogen bond)
CXC12 Y255 6.51x51 TM6 Van der Waals
CXC12 L266 6.62x62 TM6 Van der Waals
CXC12 H281 7.32x31 TM7 Van der Waals
CXC12 H281 7.32x31 TM7 polar (hydrogen bond)
CXC12 I284 7.35x34 TM7 hydrophobic
CXC12 S285 7.36x35 TM7 Van der Waals
CXC12 E288 7.39x38 TM7 polar (charge-assisted hydrogen bond)

Ligands

CXC12

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Residue Diagrams

G N G V I G T L F I I S Y I T P L F I K 1 L H L S V A D L L F V I T L P F W A V D 2 F A L I L V S S Y L N V T Y I V H V A K 3 E K V V Y V G V W I P A L L L T I P D 4 Y C S L I V I G P L I L G V M I H Q F Q F 5 V I L I L A F F A C W L P Y Y I G I S I 6 I P N L C C H F F A L A E T I S I W K 7
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ICL1 K K L R ICL1ECL1 N W Y F ECL1ICL2 A T N S Q R P R ICL2ECL2 N V S E A D D R Y I C D R F Y P N ECL2ICL3 K G H Q ICL3ECL3 I I K Q ECL3N-term M E G I S I Y T S D N Y T E E M G S G D Y D S M K E P C F N-termC-term S V S R G S S L K I L S K G K R G G H S S V S T E S E S S S F H S S C-term R E E N A N F N K I F L P T I Y S I I F L T G I V G N G L V I L V M G Y Q S M T D K Y R L H L S V A D L L F V I T L P F W A V D A V A G N F L C K A V H V I Y T V N L Y S S V L I L A F I S L D R Y L A I V H K L L A E K V V Y V G V W I P A L L L T I P D F I F A D L W V V V F Q F Q H I M V G L I L P G I V I L S C Y C I I I S K L S H S K R K A L K T T V I L I L A F F A C W L P Y Y I G I S I D S F I L L E G C E F E N T V H K W I S I T E A L A F F H C C L N P I L Y A F L G A K A Q H F K T S A L T
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Residue Table


GPCRdb(A)
GPCRdb(A)
CXCR4
TM2
2x60 2.60x60 W94
TM3
3x32 3.32x32 Y116
ECL2
45x50 45.50x50 C186
45x51 45.51x51 D187
TM6
6x51 6.51x51 Y255
6x62 6.62x62 L266
TM7
7x31 7.32x31 H281
7x34 7.35x34 I284
7x35 7.36x35 S285
7x38 7.39x38 E288