Structure information

CXCR4

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8U4P

SPECIES

Homo sapiens

RESOLUTION

3.150

PREFERRED CHAIN

R

REFERENCE

10.1038/S41594-024-01397-1

PUBLICATION DATE

March 13, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
plerixafor W94 2.60x60 TM2 hydrophobic
plerixafor Y116 3.32x32 TM3 hydrophobic
plerixafor D262 6.58x58 TM6 polar (charge-assisted hydrogen bond)
plerixafor L266 6.62x62 TM6 Van der Waals
plerixafor L266 6.62x62 TM6 hydrophobic
plerixafor E277 7.28x27 TM7 Van der Waals
plerixafor H281 7.32x31 TM7 aromatic (face-to-edge)
plerixafor H281 7.32x31 TM7 Van der Waals
plerixafor I284 7.35x34 TM7 Van der Waals
plerixafor I284 7.35x34 TM7 hydrophobic
plerixafor E288 7.39x38 TM7 polar (charge-assisted hydrogen bond)

Ligands

plerixafor

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Residue Diagrams

G N G V I G T L F I I S Y I T P L F I K 1 L H L S V A D L L F V I T L P F W A V D 2 F A L I L V S S Y L N V T Y I V H V A K 3 E K V V Y V G V W I P A L L L T I P D 4 Y C S L I V I G P L I L G V M I H Q F Q F 5 V I L I L A F F A C W L P Y Y I G I S I 6 I P N L C C H F F A L A E T I S I W K 7
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ICL1 K K L R ICL1ECL1 N W Y F ECL1ICL2 A T N S Q R P R ICL2ECL2 N V S E A D D R Y I C D R F Y P N ECL2ICL3 K G H Q ICL3ECL3 I I K Q ECL3N-term M E G I S I Y T S D N Y T E E M G S G D Y D S M K E P C F N-termC-term S V S R G S S L K I L S K G K R G G H S S V S T E S E S S S F H S S C-term R E E N A N F N K I F L P T I Y S I I F L T G I V G N G L V I L V M G Y Q S M T D K Y R L H L S V A D L L F V I T L P F W A V D A V A G N F L C K A V H V I Y T V N L Y S S V L I L A F I S L D R Y L A I V H K L L A E K V V Y V G V W I P A L L L T I P D F I F A D L W V V V F Q F Q H I M V G L I L P G I V I L S C Y C I I I S K L S H S K R K A L K T T V I L I L A F F A C W L P Y Y I G I S I D S F I L L E G C E F E N T V H K W I S I T E A L A F F H C C L N P I L Y A F L G A K A Q H F K T S A L T
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Residue Table


GPCRdb(A)
GPCRdb(A)
CXCR4
TM2
2x60 2.60x60 W94
TM3
3x32 3.32x32 Y116
TM6
6x58 6.58x58 D262
6x62 6.62x62 L266
TM7
7x27 7.28x27 E277
7x31 7.32x31 H281
7x34 7.35x34 I284
7x38 7.39x38 E288