PDB
8U8F
Resolution
3.5 Å
Released
March 6, 2024
Receptor
GPR3
Class
A
Species
Homo sapiens
Ligand
Function
palmitic acid
Agonist
Reference
10.1021/ACS.BIOCHEM.3C00647

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Ligand Amino Acid Generic Number Segment Interaction Type
palmitic acid A117 3.33x33 TM3 Van der Waals
palmitic acid F120 3.36x36 TM3 hydrophobic
palmitic acid T121 3.37x37 TM3 hydrophobic
palmitic acid I124 3.40x40 TM3 hydrophobic
palmitic acid G125 3.41x41 TM3 Van der Waals
palmitic acid V187 ECL2 hydrophobic
palmitic acid L190 ECL2 hydrophobic
palmitic acid L195 5.40x40 TM5 hydrophobic
palmitic acid L198 5.43x43 TM5 hydrophobic
palmitic acid A201 5.46x46 TM5 hydrophobic
palmitic acid F202 5.47x47 TM5 hydrophobic
palmitic acid V205 5.50x50 TM5 Van der Waals
palmitic acid F263 6.51x51 TM6 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 P A F R ICL1ECL1 C I G ECL1ICL2 A L T Y Y ICL2ECL2 V L A W N C L D G L T T C G V V Y P L ECL2ICL3 H L ICL3ECL3 D A H S ECL3N-term M M W G A G S P L A W L S A G S G N V N V S S V G P A E G P T G P A A P L P S P N-termC-term C C S S S K I P F R S R S P S D V C-term K A W D V V L C I S G T L V S C E N A L V V A I I V G T A P M F L L V G S L A V A D L L A G L G L V L H F A A V F S A E M S L V L V G V L A M A F T A S I G S L L A I T V D R Y L S L Y N S E T T V T R T Y V M L A L V W G G A L G L G L L P S K N H L V V L A I A F F M V F G I M L Q L Y A Q I C R I V C R H A Q Q I A L Q R L P A S H Y V A T R K G I A T L A V V L G A F A A C W L P F T V Y C L L G P P L Y T Y L T L L P A T Y N S M I N P I I Y A F R N Q D L W A V Q K V V C C
Helix box plot — Download: PNG | SVG A N E C S V L T G S I C L V V D W A K 1 G S L A V A D L L A G L G L V L H F A A 2 A L L S G I S A T F A M A L V G V L V L 3 T Y V M L A L V W G G A L G L G L L P 4 Y L Q L M I G F V M F F A I A L V V L H 5 A V V L G A F A A C W L P F T V Y C L L 6 I P N I M S N Y T A P L L T L Y T Y L 7

GPCRdb(A)
GPCRdb(A)
GPR3
TM3
3x33 3.33x33 A117
3x36 3.36x36 F120
3x37 3.37x37 T121
3x40 3.40x40 I124
3x41 3.41x41 G125
TM5
5x40 5.40x40 L195
5x43 5.43x43 L198
5x46 5.46x46 A201
5x47 5.47x47 F202
5x50 5.50x50 V205
TM6
6x51 6.51x51 F263