PDB
8UWL
Resolution
2.8 Å
Released
May 29, 2024
Receptor
5-HT2A
Class
A
Species
Homo sapiens
Ligand
Function
lisuride
Agonist (partial)
Reference
10.1126/SCIENCE.ADN6354

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Ligand Amino Acid Generic Number Segment Interaction Type
lisuride W151 3.28x28 TM3 hydrophobic
lisuride I152 3.29x29 TM3 Van der Waals
lisuride D155 3.32x32 TM3 polar (charge-charge)
lisuride D155 3.32x32 TM3 polar (hydrogen bond)
lisuride D155 3.32x32 TM3 hydrophobic
lisuride V156 3.33x33 TM3 Van der Waals
lisuride S159 3.36x36 TM3 Van der Waals
lisuride T160 3.37x37 TM3 Van der Waals
lisuride C227 45.50x50 ECL2 Van der Waals
lisuride F234 5.38x39 TM5 Van der Waals
lisuride S242 5.46x461 TM5 Van der Waals
lisuride W336 6.48x48 TM6 Van der Waals
lisuride F339 6.51x51 TM6 Van der Waals
lisuride F340 6.52x52 TM6 aromatic (edge-to-face)
lisuride V366 7.39x38 TM7 Van der Waals
lisuride Y370 7.43x42 TM7 Van der Waals

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ICL1 K K L Q ICL1ECL1 Y R W P L ECL1ICL2 P I H H S R F N ICL2ECL2 D S K V F K E G S C L L A ECL2ICL3 G T R A K L A S F S F L P Q S S L S S E K L F Q R S I H R E P G S Y T G R R T ICL3ECL3 K E S C ECL3N-term M D I L C E E N T S L S S T T N S L M Q L N D D T R L Y S N D F N S G E A N T S D A F N W T V D S E N R T N L S C E G C L S P S C L S L N-termC-term Q Y K E N K K P L Q L I L V N T I P A L A Y K S S Q L Q M G Q K K N S K Q D A K T T D N D C S M V A L G K Q H S E E A S K D N S D G V N E K V S C V C-term L H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E A T L C V S D L M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T F S R Y R S A Y I Q C
Helix box plot — Download: PNG | SVG I N G A I T L I I V V A T L L A S W N K 1 M S L A I A D M L L G L F V M P V S M L T 2 A C L H M I S A T S F L V D L Y I W V A 3 A F L K I I A V W T I S V G I S M P I 4 Y T I V M I T L P I F F S V F S G I L V F 5 G I V F F L F V V M W C P F F I T N I M 6 L P N V A S S L Y G I W V F V N L L A 7

GPCRdb(A)
GPCRdb(A)
5-HT2A receptor
TM3
3x28 3.28x28 W151
3x29 3.29x29 I152
3x32 3.32x32 D155
3x33 3.33x33 V156
3x36 3.36x36 S159
3x37 3.37x37 T160
ECL2
45x50 45.50x50 C227
TM5
5x39 5.38x39 F234
5x461 5.46x461 S242
TM6
6x48 6.48x48 W336
6x51 6.51x51 F339
6x52 6.52x52 F340
TM7
7x38 7.39x38 V366
7x42 7.43x42 Y370