PDB
8UXY
Resolution
3.3 Å
Released
Oct. 30, 2024
Receptor
OR1F1
Class
O2
Species
Homo sapiens
Ligand
Levomenthol
Function
Agonist
Reference
10.1038/S41586-024-08126-0

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Ligand Amino Acid Generic Number Segment Interaction Type
Levomenthol F104 3.32x32 TM3 hydrophobic
Levomenthol N109 3.37x37 TM3 Van der Waals
Levomenthol N109 3.37x37 TM3 polar (hydrogen bond)
Levomenthol H159 4.60x60 TM4 Van der Waals
Levomenthol I199 5.39x39 TM5 Van der Waals
Levomenthol I207 5.47x47 TM5 hydrophobic
Levomenthol I207 5.47x47 TM5 Van der Waals
Levomenthol Y259 6.55x55 TM6 Van der Waals
Levomenthol Y259 6.55x55 TM6 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 S C L H ICL1ECL1 E T Q T I ECL1ICL2 P L H Y T A K M ICL2ECL2 P L S F C A D N A I T H F F C D V T P L L K L S C S D ECL2ICL3 V P ICL3ECL3 N P L S S H ECL3N-term M S G T N Q S S V S E F L L L G L S R N-termC-term V C-term Q P Q Q Q H L L F V F F L S M Y L A T V L G N L L I I L S V S I D T P M Y F F L S N L S F V D I C F S F T T V P K M L A N H I L S F C G C L T Q M Y F V F M F V D M D N F L L A V M A Y D H F V A V C H T H Q L C A L L V A G L W V V A N L N V L L H T L L M A T H L N E V I I L S E G A L V M I T P F L C I L A S Y M H I T C T V L K S T K G R W K A F S T C G S H L A V V L L F Y S T I I A V Y F S A E K D T M A T V L Y T V V T P M L N P F I Y S L R N R Y L K K V V F L K G A V V G R S
Helix box plot — Download: PNG | SVG L N G L V T A L Y M S L F F V F L L H Q 1 S N L S F V D I C F S F T T V P K M L A 2 V A L L F N D M D V F M F V F Y M Q T L 3 C A L L V A G L W V V A N L N V L L H T 4 Y S A L I C L F P T I M V L A G E S L I 5 G S H L A V V L L F Y S T I I A V Y F 6 F P N L M P T V V T Y L V T A M T D K 7

GPCRdb(A)
GPCRdb(A)
OR1F1
TM3
3x32 3.32x32 V104
3x37 3.37x37 D109
TM4
4x60 4.60x60 H159
TM5
5x39 5.39x39 I199
5x47 5.47x47 M207
TM6
6x55 6.55x55 Y259