PDB
8V6U
Resolution
3.0 Å
Released
May 29, 2024
Receptor
5-HT2A
Class
A
Species
Homo sapiens
Ligand
Z7757
Function
Agonist
Reference
10.1126/SCIENCE.ADN6354

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
Z7757 D155 3.32x32 TM3 polar (charge-assisted hydrogen bond)
Z7757 V156 3.33x33 TM3 Van der Waals
Z7757 V156 3.33x33 TM3 hydrophobic
Z7757 S159 3.36x36 TM3 Van der Waals
Z7757 L228 45.51x51 ECL2 Van der Waals
Z7757 L228 45.51x51 ECL2 hydrophobic
Z7757 G238 5.42x43 TM5 polar (hydrogen bond with backbone)
Z7757 G238 5.42x43 TM5 Van der Waals
Z7757 S242 5.46x461 TM5 polar (hydrogen bond)
Z7757 F339 6.51x51 TM6 aromatic (edge-to-face)
Z7757 F339 6.51x51 TM6 Van der Waals
Z7757 F340 6.52x52 TM6 Van der Waals
Z7757 F340 6.52x52 TM6 aromatic (edge-to-face)
Z7757 V366 7.39x38 TM7 hydrophobic
Z7757 V366 7.39x38 TM7 Van der Waals
Z7757 Y370 7.43x42 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 K K L Q ICL1ECL1 Y R W P L ECL1ICL2 P I H H S R F N ICL2ECL2 D S K V F K E G S C L L A ECL2ICL3 G T R A K L A S F S F L P Q S S L S S E K L F Q R S I H R E P G S Y T G R R T ICL3ECL3 K E S C ECL3N-term M D I L C E E N T S L S S T T N S L M Q L N D D T R L Y S N D F N S G E A N T S D A F N W T V D S E N R T N L S C E G C L S P S C L S L N-termC-term Q Y K E N K K P L Q L I L V N T I P A L A Y K S S Q L Q M G Q K K N S K Q D A K T T D N D C S M V A L G K Q H S E E A S K D N S D G V N E K V S C V C-term L H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E A T L C V S D L M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T F S R Y R S A Y I Q C
Helix box plot — Download: PNG | SVG I N G A I T L I I V V A T L L A S W N K 1 M S L A I A D M L L G L F V M P V S M L T 2 A C L H M I S A T S F L V D L Y I W V A 3 A F L K I I A V W T I S V G I S M P I 4 Y T I V M I T L P I F F S V F S G I L V F 5 G I V F F L F V V M W C P F F I T N I M 6 L P N V A S S L Y G I W V F V N L L A 7

GPCRdb(A)
GPCRdb(A)
5-HT2A receptor
TM3
3x32 3.32x32 D155
3x33 3.33x33 V156
3x36 3.36x36 S159
ECL2
45x51 45.51x51 L228
TM5
5x43 5.42x43 G238
5x461 5.46x461 S242
TM6
6x51 6.51x51 F339
6x52 6.52x52 F340
TM7
7x38 7.39x38 V366
7x42 7.43x42 Y370