PDB
8VVE
Resolution
3.3 Å
Released
Jan. 15, 2025
Receptor
κ
Class
A
Species
Homo sapiens
Ligand
Function
nor-binaltorphimine
Inverse agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
nor-binaltorphimine V108 2.53x53 TM2 hydrophobic
nor-binaltorphimine Q115 2.60x60 TM2 Van der Waals
nor-binaltorphimine D138 3.32x32 TM3 polar (hydrogen bond)
nor-binaltorphimine D138 3.32x32 TM3 polar (charge-charge)
nor-binaltorphimine Y139 3.33x33 TM3 hydrophobic
nor-binaltorphimine M142 3.36x36 TM3 hydrophobic
nor-binaltorphimine S211 45.51x51 ECL2 polar (hydrogen bond)
nor-binaltorphimine V230 5.42x43 TM5 Van der Waals
nor-binaltorphimine W287 6.48x48 TM6 hydrophobic
nor-binaltorphimine I290 6.51x51 TM6 hydrophobic
nor-binaltorphimine H291 6.52x52 TM6 aromatic (edge-to-face)
nor-binaltorphimine I294 6.55x55 TM6 hydrophobic
nor-binaltorphimine H304 ECL3 hydrophobic
nor-binaltorphimine A308 7.31x30 TM7 hydrophobic
nor-binaltorphimine Y312 7.35x34 TM7 aromatic (pi-cation)
nor-binaltorphimine Y312 7.35x34 TM7 hydrophobic
nor-binaltorphimine Y320 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 S W P F ECL1ICL2 P V K A L D F R ICL2ECL2 G T K V R E D V D V I E C S L Q F P D D ECL2ICL3 R L L S G ICL3ECL3 S T S H ECL3N-term M D S P I Q I F R G E P G P T C A P S A C L P P N S S A W F P G W A E P D S N G S A G S E D A Q L E P A H I S P N-termC-term P L K M R M E R Q S T S R V R N T V Q D P A Y L R D I D G M N K P V C-term A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N G D V L C K I V I S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H T P L K A K I I N I C I W L L S S S V G I S A I V L G D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F R D F K R C F C F
Helix box plot — Download: PNG | SVG S N G V L G V V F V V S Y V A T I I V P 1 F N L A L A D A L V T T T M P F Q S T V 2 M T L T F I S T F M N Y Y D I S I V I K 3 A K I I N I C I W L L S S S V G I S A I 4 Y C V I I I L V P I V F A F I F V C I K M 5 L V V V A V F V V C W T P I H I F I L V 6 I P N L S S N T Y G L A I C F Y Y S S 7

GPCRdb(A)
GPCRdb(A)
κ receptor
TM2
2x53 2.53x53 V108
2x60 2.60x60 Q115
TM3
3x32 3.32x32 D138
3x33 3.33x33 Y139
3x36 3.36x36 M142
ECL2
45x51 45.51x51 S211
TM5
5x43 5.42x43 V230
TM6
6x48 6.48x48 W287
6x51 6.51x51 I290
6x52 6.52x52 H291
6x55 6.55x55 I294
TM7
7x30 7.31x30 A308
7x34 7.35x34 Y312
7x42 7.43x42 Y320