PDB
8VVG
Resolution
3.3 Å
Released
Jan. 15, 2025
Receptor
κ
Class
A
Species
Homo sapiens
Ligand
GB18
Function
Inverse agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
GB18 I135 3.29x29 TM3 hydrophobic
GB18 D138 3.32x32 TM3 polar (charge-assisted hydrogen bond)
GB18 Y139 3.33x33 TM3 Van der Waals
GB18 Y139 3.33x33 TM3 hydrophobic
GB18 M142 3.36x36 TM3 hydrophobic
GB18 M142 3.36x36 TM3 Van der Waals
GB18 F143 3.37x37 TM3 Van der Waals
GB18 F143 3.37x37 TM3 hydrophobic
GB18 W287 6.48x48 TM6 hydrophobic
GB18 W287 6.48x48 TM6 Van der Waals
GB18 I290 6.51x51 TM6 hydrophobic
GB18 I290 6.51x51 TM6 Van der Waals
GB18 H291 6.52x52 TM6 polar (hydrogen bond)
GB18 H291 6.52x52 TM6 Van der Waals
GB18 I294 6.55x55 TM6 Van der Waals
GB18 I294 6.55x55 TM6 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 S W P F ECL1ICL2 P V K A L D F R ICL2ECL2 G T K V R E D V D V I E C S L Q F P D D ECL2ICL3 R L L S G ICL3ECL3 S T S H ECL3N-term M D S P I Q I F R G E P G P T C A P S A C L P P N S S A W F P G W A E P D S N G S A G S E D A Q L E P A H I S P N-termC-term P L K M R M E R Q S T S R V R N T V Q D P A Y L R D I D G M N K P V C-term A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N G D V L C K I V I S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H T P L K A K I I N I C I W L L S S S V G I S A I V L G D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F R D F K R C F C F
Helix box plot — Download: PNG | SVG S N G V L G V V F V V S Y V A T I I V P 1 F N L A L A D A L V T T T M P F Q S T V 2 M T L T F I S T F M N Y Y D I S I V I K 3 A K I I N I C I W L L S S S V G I S A I 4 Y C V I I I L V P I V F A F I F V C I K M 5 L V V V A V F V V C W T P I H I F I L V 6 I P N L S S N T Y G L A I C F Y Y S S 7

GPCRdb(A)
GPCRdb(A)
κ receptor
TM3
3x29 3.29x29 I135
3x32 3.32x32 D138
3x33 3.33x33 Y139
3x36 3.36x36 M142
3x37 3.37x37 F143
TM6
6x48 6.48x48 W287
6x51 6.51x51 I290
6x52 6.52x52 H291
6x55 6.55x55 I294