PDB
8VY7
Resolution
2.7 Å
Released
April 3, 2024
Receptor
TAS2R14
Class
T2
Species
Homo sapiens
Ligands
Cholesterol
compound 28.1 [PMID: 36847646]
Function
Agonist
Ago-PAM
Reference
—
Cholesterol compound 28.1 [PMID: 36847646]

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Ligand Amino Acid Generic Number Segment Interaction Type
Cholesterol F76 ECL1 hydrophobic
Cholesterol F82 3.25x25 TM3 hydrophobic
Cholesterol W89 3.32x32 TM3 hydrophobic
compound 28.1 [PMID: 36847646] Y107 3.50x50 TM3 aromatic (edge-to-face)
Cholesterol R174 ECL2 polar (charge-assisted hydrogen bond)
Cholesterol V180 5.40x41 TM5 hydrophobic
Cholesterol V180 5.40x41 TM5 Van der Waals
Cholesterol T184 5.44x45 TM5 Van der Waals
Cholesterol I187 5.47x47 TM5 hydrophobic
compound 28.1 [PMID: 36847646] M197 5.57x57 TM5 hydrophobic
compound 28.1 [PMID: 36847646] F198 5.58x58 TM5 aromatic (edge-to-face)
compound 28.1 [PMID: 36847646] L201 5.61x61 TM5 hydrophobic
compound 28.1 [PMID: 36847646] V230 6.35x35 TM6 hydrophobic
compound 28.1 [PMID: 36847646] V233 6.38x38 TM6 hydrophobic
Cholesterol F247 6.52x52 TM6 Van der Waals
Cholesterol F247 6.52x52 TM6 hydrophobic
Cholesterol I262 7.35x34 TM7 hydrophobic
Cholesterol I262 7.35x34 TM7 Van der Waals
Cholesterol S265 7.38x37 TM7 Van der Waals
Cholesterol M268 7.41x40 TM7 hydrophobic
Cholesterol M268 7.41x40 TM7 Van der Waals
Cholesterol G269 7.42x41 TM7 Van der Waals
compound 28.1 [PMID: 36847646] H276 7.49x49 TM7 polar (hydrogen bond)
compound 28.1 [PMID: 36847646] H276 7.49x49 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R K I ICL1ECL1 P A L F A ECL1ICL2 N F S N S I F L Y L K W ICL2ECL2 A S I N G Y R R N K T C S S D S S N F T R F S S L ECL2ICL3 K I S G D A S T K A ICL3ECL3 E E ECL3C-term G E P S G H K E F R E S S C-term M G G V I K S I F T F V L I V E F I I G N L G N S F I A L V N C I D W V K G S S V D R I L T A L A I S R I S L V W L I F G S W C V S V F F T E K M F R M L T N I W T V I N H F S V W L A T G L G T F Y F L K I A R V K K V V L V L L L V T S V F L F L N I A L I N I H I N I V L T S T V F I F I P F T L S L A M F L L L I F S M W K H R K K M Q H T V H R G V K S V I T F F L L Y A I F S L S F F I S V W T S E R L N L I I L S Q V M G M A Y P S C H S C V L I L G N K K S L S L R Y L R Q A V L L W M F K D
Helix box plot — Download: PNG | SVG S N G L N G I I F E V I L V F T F I S K 1 T A L A I S R I S L V W L I F G S W C V 2 G T A L W V S F H N I V T W I N T L M R 3 V L V L L L V T S V F L F L N I A L I N 4 F M A L S L T F P I F I F V T S T L V I 5 V I T F F L L Y A I F S L S F F I S V W 6 C S H C S P Y A M G M V Q S L I I L N 7

GPCRdb(A)
GPCRdb(A)
TAS2R14
TM3
3x25 3.25x25 F82
3x32 3.32x32 W89
3x50 3.50x50 Y107
TM5
5x41 5.40x41 V180
5x45 5.44x45 T184
5x47 5.47x47 I187
5x57 5.57x57 M197
5x58 5.58x58 F198
5x61 5.61x61 L201
TM6
6x35 6.35x35 V230
6x38 6.38x38 V233
6x52 6.52x52 F247
TM7
7x34 7.35x34 I262
7x37 7.38x37 S265
7x40 7.41x40 M268
7x41 7.42x41 G269
7x49 7.49x49 H276