| Ligand | Amino Acid | Generic Number | Segment | Interaction Type |
|---|---|---|---|---|
| Cholesterol | F76 | ECL1 | hydrophobic | |
| Cholesterol | F82 | 3.25x25 | TM3 | hydrophobic |
| Cholesterol | L85 | 3.28x28 | TM3 | hydrophobic |
| Cholesterol | W89 | 3.32x32 | TM3 | hydrophobic |
| compound 28.1 [PMID: 36847646] | Y107 | 3.50x50 | TM3 | hydrophobic |
| Cholesterol | V180 | 5.40x41 | TM5 | hydrophobic |
| Cholesterol | I187 | 5.47x47 | TM5 | hydrophobic |
| compound 28.1 [PMID: 36847646] | M197 | 5.57x57 | TM5 | hydrophobic |
| compound 28.1 [PMID: 36847646] | F198 | 5.58x58 | TM5 | aromatic (edge-to-face) |
| compound 28.1 [PMID: 36847646] | L201 | 5.61x61 | TM5 | hydrophobic |
| compound 28.1 [PMID: 36847646] | V230 | 6.35x35 | TM6 | hydrophobic |
| compound 28.1 [PMID: 36847646] | V233 | 6.38x38 | TM6 | hydrophobic |
| compound 28.1 [PMID: 36847646] | F237 | 6.42x42 | TM6 | aromatic (face-to-edge) |
| Cholesterol | F247 | 6.52x52 | TM6 | hydrophobic |
| Cholesterol | I262 | 7.35x34 | TM7 | hydrophobic |
| Cholesterol | M268 | 7.41x40 | TM7 | hydrophobic |
| compound 28.1 [PMID: 36847646] | H276 | 7.49x49 | TM7 | Van der Waals |
| compound 28.1 [PMID: 36847646] | H276 | 7.49x49 | TM7 | polar (hydrogen bond) |
| compound 28.1 [PMID: 36847646] | G283 | 7.56x56 | TM7 | Van der Waals |
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|
GPCRdb(A)
|
GPCRdb(A)
|
TAS2R14
|
|---|---|---|
| TM3 | ||
| 3x25 | 3.25x25 | F82 |
| 3x28 | 3.28x28 | L85 |
| 3x32 | 3.32x32 | W89 |
| 3x50 | 3.50x50 | Y107 |
| TM5 | ||
| 5x41 | 5.40x41 | V180 |
| 5x47 | 5.47x47 | I187 |
| 5x57 | 5.57x57 | M197 |
| 5x58 | 5.58x58 | F198 |
| 5x61 | 5.61x61 | L201 |
| TM6 | ||
| 6x35 | 6.35x35 | V230 |
| 6x38 | 6.38x38 | V233 |
| 6x42 | 6.42x42 | F237 |
| 6x52 | 6.52x52 | F247 |
| TM7 | ||
| 7x34 | 7.35x34 | I262 |
| 7x40 | 7.41x40 | M268 |
| 7x49 | 7.49x49 | H276 |
| 7x56 | 7.56x56 | G283 |