PDB
8W89
Resolution
3.0 Å
Released
Nov. 22, 2023
Receptor
TA1
Class
A
Species
Homo sapiens
Ligand
β-phenylethylamine
Function
Agonist
Reference
10.1038/S41586-023-06775-1

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Ligand Amino Acid Generic Number Segment Interaction Type
β-phenylethylamine D103 3.32x32 TM3 polar (charge-charge)
β-phenylethylamine I104 3.33x33 TM3 hydrophobic
β-phenylethylamine I104 3.33x33 TM3 Van der Waals
β-phenylethylamine S107 3.36x36 TM3 polar (charge-assisted hydrogen bond)
β-phenylethylamine F186 ECL2 hydrophobic
β-phenylethylamine F186 ECL2 Van der Waals
β-phenylethylamine T194 5.42x43 TM5 Van der Waals
β-phenylethylamine W264 6.48x48 TM6 Van der Waals
β-phenylethylamine F267 6.51x51 TM6 Van der Waals
β-phenylethylamine F267 6.51x51 TM6 aromatic (edge-to-face)
β-phenylethylamine F268 6.52x52 TM6 hydrophobic
β-phenylethylamine F268 6.52x52 TM6 Van der Waals
β-phenylethylamine Y294 7.43x42 TM7 polar (charge-assisted hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 K Q L H ICL1ECL1 C W Y F ECL1ICL2 P L R Y K A K M ICL2ECL2 L N F K G A E E I Y Y K H V H C R G G C S V F F ECL2ICL3 I G L E M K ICL3ECL3 H Y I I ECL3N-term M M P F C H N I I N I S C V K N N W S N N-termC-term G K I F Q K D S S R C K L F L E L S S C-term D V R A S L Y S L M V L I I L T T L V G N L I V I V S I S H F T P T N W L I H S M A T V D F L L G C L V M P Y S M V R S A E H G E V F C K I H T S T D I M L S S A S I F H L S F I S I D R Y Y A V C D N I L V I C V M I F I S W S V P A V F A F G M I F L E S K I S G V L T F M T S F Y I P G S I M L C V Y Y R I Y L I A K E Q A R L I S D A N Q K L Q N G I S Q S K E R K A V K T L G I V M G V F L I C W C P F F I C T V M D P F L P P T L N D V L I W F G Y L N S T F N P M V Y A F F Y P W L K M F R K A M L F
Helix box plot — Download: PNG | SVG L N G V L T T L I I L V M L S Y L S A R 1 H S M A T V D F L L G L C V M P Y S M V R 2 F S L H F I S A S S L M I D T S T H I K 3 I C V M I F I S W S V P A V F A F G M I 4 Y V C L M I S G P I Y F S T M F T L V G S 5 G I V M G V F L I C W C P F F I C T V M 6 M P N F T S N L Y G F W I L V D N L T 7

GPCRdb(A)
GPCRdb(A)
TA1 receptor
TM3
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 S107
TM5
5x43 5.42x43 T194
TM6
6x48 6.48x48 W264
6x51 6.51x51 F267
6x52 6.52x52 F268
TM7
7x42 7.43x42 Y294