PDB
8W8S
Resolution
3.3 Å
Released
Jan. 3, 2024
Receptor
GPR101
Class
A
Species
Homo sapiens
Ligand
AA-14
Function
Allosteric agonist
Reference
10.1038/S41589-023-01456-6

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Ligand Amino Acid Generic Number Segment Interaction Type
AA-14 W441 7.40x39 TM7 hydrophobic

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ICL1 P Q L L ICL1ECL1 L F W P L ECL1ICL2 P L S Y P S K M ICL2ECL2 W G Q A A F D E R N A L C S M I W G A ECL2ICL3 K R H S L E V R V K D C V E N E D E E G A E K K E E F Q D E S E F R R Q H E G E V K A K E G R M E A K D G S L K A K E G S T G T S E S S V E A R G S E E V R E S S T V A S D G S M E G K E G S T K V E E N S M K A D K G R T E V N Q C S I D L G E D D M E F G E D D I N F S E D D V E A V N I P E S L P P S R R N S N S N P ICL3ECL3 D V E T Q V ECL3N-term M T S T C T N S T R E S N S S H T C M P L S K M P I N-termC-term C K E K P P K E D S H P D L P G T E G G T E G K I V P S Y D S A T F P C-term S L A H G I I R S T V L V I F L A A S F V G N I V L A L V L Q R K Q V T N R F I F N L L V T D L L Q I S L V A P W V V A T S V P N S H F C T A L V S L T H L F A F A S V N T I V V V S V D R Y L S I I H T Q R R G Y L L L Y G T W I V A I L Q S T P P L Y G S P S Y T I L S V V S F I V I P L I V M I A C Y S V V F C A A R R Q H A L L Y N V P L P R C Y Q C K A A K V I F I I I F S Y V L S L G P Y C F L A V L A V W V P Q W V I T I I I W L F F L Q C C I H P Y V Y G Y M H K T I Q D F F I K K E M L K K
Helix box plot — Download: PNG | SVG I N G V F S A A L F I V L V T S R I I G 1 F N L L V T D L L Q I L S V A P W V V A T 2 V V I T N V S A F A F L H T L S V L A T 3 G Y L L L Y G T W I V A I L Q S T P P L 4 Y C A I M V I L P I V I F S V V S L I T Y 5 F I I I F S Y V L S L G P Y C F L A V L 6 Y P H I C C Q L F F L W I I I T I V W 7

GPCRdb(A)
GPCRdb(A)
GPR101
TM7
7x39 7.40x39 W441