| Ligand | Amino Acid | Generic Number | Segment | Interaction Type |
|---|---|---|---|---|
| γ-MSH (Human) | F45 | 1.39x39 | TM1 | Van der Waals |
| γ-MSH (Human) | E94 | 2.60x60 | TM2 | Van der Waals |
| γ-MSH (Human) | T95 | 2.61x61 | TM2 | polar (hydrogen bond) |
| γ-MSH (Human) | M97 | 2.63x63 | TM2 | hydrophobic |
| γ-MSH (Human) | I98 | 2.64x64 | TM2 | hydrophobic |
| γ-MSH (Human) | D110 | 3.18x18 | TM3 | polar (charge-charge) |
| γ-MSH (Human) | I113 | 3.21x21 | TM3 | hydrophobic |
| γ-MSH (Human) | Q114 | 3.22x22 | TM3 | Van der Waals |
| γ-MSH (Human) | D117 | 3.25x25 | TM3 | polar (hydrogen bond) |
| γ-MSH (Human) | D117 | 3.25x25 | TM3 | polar (charge-charge) |
| γ-MSH (Human) | D117 | 3.25x25 | TM3 | hydrophobic |
| Calcium | D117 | 3.25x25 | TM3 | polar (charge-charge) |
| γ-MSH (Human) | N118 | 3.26x26 | TM3 | polar (hydrogen bond) |
| Calcium | D121 | 3.29x29 | TM3 | metal coordination |
| γ-MSH (Human) | D121 | 3.29x29 | TM3 | polar (charge-charge) |
| γ-MSH (Human) | I124 | 3.32x32 | TM3 | hydrophobic |
| γ-MSH (Human) | F179 | 4.60x60 | TM4 | Van der Waals |
| γ-MSH (Human) | I180 | 4.61x61 | TM4 | hydrophobic |
| γ-MSH (Human) | E184 | ECL2 | polar (hydrogen bond) | |
| γ-MSH (Human) | E184 | ECL2 | polar (charge-charge) | |
| γ-MSH (Human) | S185 | ECL2 | Van der Waals | |
| γ-MSH (Human) | V188 | 5.39x39 | TM5 | hydrophobic |
| γ-MSH (Human) | I189 | 5.40x40 | TM5 | Van der Waals |
| γ-MSH (Human) | L192 | 5.43x43 | TM5 | hydrophobic |
| γ-MSH (Human) | F258 | 6.51x51 | TM6 | hydrophobic |
| γ-MSH (Human) | H261 | 6.54x54 | TM6 | polar (hydrogen bond) |
| γ-MSH (Human) | L262 | 6.55x55 | TM6 | hydrophobic |
| γ-MSH (Human) | I265 | ECL3 | Van der Waals | |
| γ-MSH (Human) | F281 | 7.35x34 | TM7 | hydrophobic |
| γ-MSH (Human) | N282 | 7.36x35 | TM7 | Van der Waals |
| γ-MSH (Human) | L285 | 7.39x38 | TM7 | hydrophobic |
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|
GPCRdb(A)
|
GPCRdb(A)
|
MC3 receptor
|
|---|---|---|
| TM1 | ||
| 1x39 | 1.39x39 | F45 |
| TM2 | ||
| 2x60 | 2.60x60 | E94 |
| 2x61 | 2.61x61 | T95 |
| 2x63 | 2.63x63 | M97 |
| 2x64 | 2.64x64 | I98 |
| TM3 | ||
| 3x18 | 3.18x18 | D110 |
| 3x21 | 3.21x21 | I113 |
| 3x22 | 3.22x22 | Q114 |
| 3x25 | 3.25x25 | D117 |
| 3x26 | 3.26x26 | N118 |
| 3x29 | 3.29x29 | D121 |
| 3x32 | 3.32x32 | I124 |
| TM4 | ||
| 4x60 | 4.60x60 | F179 |
| 4x61 | 4.61x61 | I180 |
| TM5 | ||
| 5x39 | 5.39x39 | V188 |
| 5x40 | 5.40x40 | I189 |
| 5x43 | 5.43x43 | L192 |
| TM6 | ||
| 6x51 | 6.51x51 | F258 |
| 6x54 | 6.54x54 | H261 |
| 6x55 | 6.55x55 | L262 |
| TM7 | ||
| 7x34 | 7.35x34 | F281 |
| 7x35 | 7.36x35 | N282 |
| 7x38 | 7.39x38 | L285 |