PDB
8WC6
Resolution
3.2 Å
Released
Dec. 27, 2023
Receptor
TA1
Class
A
Species
Mus musculus
Ligand
β-phenylethylamine
Function
Agonist
Reference
10.1016/J.CELL.2023.10.014

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Ligand Amino Acid Generic Number Segment Interaction Type
β-phenylethylamine D102 3.32x32 TM3 polar (charge-charge)
β-phenylethylamine I103 3.33x33 TM3 hydrophobic
β-phenylethylamine I103 3.33x33 TM3 Van der Waals
β-phenylethylamine S106 3.36x36 TM3 Van der Waals
β-phenylethylamine F185 ECL2 hydrophobic
β-phenylethylamine F185 ECL2 Van der Waals
β-phenylethylamine F264 6.51x51 TM6 Van der Waals
β-phenylethylamine F264 6.51x51 TM6 aromatic (edge-to-face)
β-phenylethylamine F265 6.52x52 TM6 hydrophobic
β-phenylethylamine Y291 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K Q L H ICL1ECL1 C W Y F ECL1ICL2 P L R Y K A K I ICL2ECL2 L N L K G V E E L Y R S Q V S D L G G C S P F F ECL2ICL3 L E G K S Q ICL3ECL3 Y V I ECL3N-term M H L C H A I T N I S H R N S D W S R E N-termC-term G K I F Q K D S S R S K L F L C-term V Q A S L Y S L M S L I I L A T L V G N L I V I I S I S H F T P T N W L L H S M A I V D F L L G C L I M P C S M V R T V E R G E I L C K V H T S T D I M L S S A S I F H L A F I S I D R Y C A V C D N I S T I L V M I L V S W S L P A V Y A F G M I F L E S K V S G V L A F M T S F Y I P G S V M L F V Y Y R I Y F I A K G Q A R S I N R T N V Q V G A P Q S K E T K A A K T L G I M V G V F L V C W C P F F L C T V L D P F L G P P S L N D A L Y W F G Y L N S A L N P M V Y A F F Y P W L K M F R R A V L L
Helix box plot — Download: PNG | SVG L N G V L T A L I I L S M L S Y L S A Q 1 H S M A I V D F L L G L C I M P C S M V R 2 F A L H F I S A S S L M I D T S T H V K 3 I L V M I L V S W S L P A V Y A F G M I 4 Y V F L M V S G P I Y F S T M F A L V G S 5 G I M V G V F L V C W C P F F L C T V L 6 M P N L A S N L Y G F W Y L A D N L S 7

GPCRdb(A)
GPCRdb(A)
TA1 receptor
TM3
3x32 3.32x32 D102
3x33 3.33x33 I103
3x36 3.36x36 S106
TM6
6x51 6.51x51 F264
6x52 6.52x52 F265
TM7
7x42 7.43x42 Y291