PDB
8WC9
Resolution
3.2 Å
Released
Dec. 27, 2023
Receptor
TA1
Class
A
Species
Mus musculus
Ligand
Function
CHEMBL476516
Agonist
Reference
10.1016/J.CELL.2023.10.014

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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL476516 D102 3.32x32 TM3 polar (hydrogen bond)
CHEMBL476516 D102 3.32x32 TM3 polar (charge-charge)
CHEMBL476516 I103 3.33x33 TM3 Van der Waals
CHEMBL476516 S106 3.36x36 TM3 Van der Waals
CHEMBL476516 Y153 4.56x56 TM4 Van der Waals
CHEMBL476516 A193 5.42x43 TM5 hydrophobic
CHEMBL476516 S197 5.46x461 TM5 Van der Waals
CHEMBL476516 W261 6.48x48 TM6 Van der Waals
CHEMBL476516 F264 6.51x51 TM6 hydrophobic
CHEMBL476516 F264 6.51x51 TM6 aromatic (edge-to-face)
CHEMBL476516 F265 6.52x52 TM6 hydrophobic
CHEMBL476516 F265 6.52x52 TM6 aromatic (edge-to-face)
CHEMBL476516 Y287 7.39x38 TM7 hydrophobic
CHEMBL476516 Y291 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K Q L H ICL1ECL1 C W Y F ECL1ICL2 P L R Y K A K I ICL2ECL2 L N L K G V E E L Y R S Q V S D L G G C S P F F ECL2ICL3 L E G K S Q ICL3ECL3 Y V I ECL3N-term M H L C H A I T N I S H R N S D W S R E N-termC-term G K I F Q K D S S R S K L F L C-term V Q A S L Y S L M S L I I L A T L V G N L I V I I S I S H F T P T N W L L H S M A I V D F L L G C L I M P C S M V R T V E R G E I L C K V H T S T D I M L S S A S I F H L A F I S I D R Y C A V C D N I S T I L V M I L V S W S L P A V Y A F G M I F L E S K V S G V L A F M T S F Y I P G S V M L F V Y Y R I Y F I A K G Q A R S I N R T N V Q V G A P Q S K E T K A A K T L G I M V G V F L V C W C P F F L C T V L D P F L G P P S L N D A L Y W F G Y L N S A L N P M V Y A F F Y P W L K M F R R A V L L
Helix box plot — Download: PNG | SVG L N G V L T A L I I L S M L S Y L S A Q 1 H S M A I V D F L L G L C I M P C S M V R 2 F A L H F I S A S S L M I D T S T H V K 3 I L V M I L V S W S L P A V Y A F G M I 4 Y V F L M V S G P I Y F S T M F A L V G S 5 G I M V G V F L V C W C P F F L C T V L 6 M P N L A S N L Y G F W Y L A D N L S 7

GPCRdb(A)
GPCRdb(A)
TA1 receptor
TM3
3x32 3.32x32 D102
3x33 3.33x33 I103
3x36 3.36x36 S106
TM4
4x56 4.56x56 Y153
TM5
5x43 5.42x43 A193
5x461 5.46x461 S197
TM6
6x48 6.48x48 W261
6x51 6.51x51 F264
6x52 6.52x52 F265
TM7
7x38 7.39x38 Y287
7x42 7.43x42 Y291