PDB
8WG8
Resolution
2.7 Å
Released
March 6, 2024
Receptor
glucagon
Class
B1
Species
Homo sapiens
Ligand
Function
Unknown peptide (Chain X)
Unknown
Reference
10.1038/S41421-024-00649-0

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Ligand Amino Acid Generic Number Segment Interaction Type
Unknown peptide (Chain X) L266 4.44x45 TM4 Van der Waals
Unknown peptide (Chain X) A274 4.52x52 TM4 Van der Waals
Unknown peptide (Chain X) L277 4.55x55 TM4 hydrophobic
Unknown peptide (Chain X) F278 4.56x56 TM4 hydrophobic
Unknown peptide (Chain X) W282 4.60x60 TM4 hydrophobic
Unknown peptide (Chain X) F303 ECL2 Van der Waals
Unknown peptide (Chain X) I306 5.38x381 TM5 hydrophobic
Unknown peptide (Chain X) L307 5.39x39 TM5 Van der Waals
Unknown peptide (Chain X) F309 5.41x41 TM5 Van der Waals
Unknown peptide (Chain X) P310 5.42x42 TM5 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 S K L H ICL1ECL1 Q K I G D D L S V S T W L S D G ECL1ICL2 A T L P E R ICL2ECL2 N V Q C W T S N D N M G F ECL2ICL3 R Q M H H T ICL3ECL3 E H A Q ECL3N-term M P P C Q P Q R P L L L L L L L L A C Q P Q V P S A Q V M D F L F E K W K L Y G D Q C H H N L S L L P P P T E L V C N R T F D K Y S C W P D T P A N T T A N I S C P W Y L P W H H K V Q H R F V F K R C G P D G Q W V R G P R G Q P W R D A S Q C Q M D G E E I E V N-termC-term T S N H R A S S S P G H G P P S K E L Q F G R G G G S Q D S S A E T P L A G G L P R L A E S P F C-term Q K E V A K M Y S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T R Y S A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G L S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A D Y K F R L A K S T L T L I P L L G V H E V V F A F V T D G T L R S A K L F F D L F L S S F Q G L L V A V L Y C F L N K E L R R W R L W E E V Q S E R W H R G K V L R N
Helix box plot — Download: PNG | SVG L L A G L S L S Y G V T Y M V Q F S S Y 1 A N L F A S F V L K A S S V L V I D G L 2 V L L W C Y N A V I G Y Q M F V A A V R 3 F F S L Y L G G I W G A P M L F V V P W A 4 F I F F N I L I A L F V P F R L I W W 5 L T L I P L L G V H E V V F A F V T D 6 V A V L L G Q F S S L F L D F F L K A 7

GPCRdb(A)
GPCRdb(B)
glucagon receptor
TM4
4x45 4.44x45 L266
4x52 4.52x52 A274
4x55 4.55x55 L277
4x56 4.56x56 F278
4x60 4.60x60 W282
TM5
5x421 5.38x381 I306
5x43 5.39x39 L307
5x45 5.41x41 F309
5x46 5.42x42 P310