PDB
8WGB
Resolution
3.7 Å
Released
Oct. 30, 2024
Receptor
mGlu4
Class
C
Species
Homo sapiens
Ligands
L-glutamic acid
VU0155041
Function
Agonist
PAM
Reference
10.1038/S41467-024-54744-7
L-glutamic acid VU0155041

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Ligand Amino Acid Generic Number Segment Interaction Type
L-glutamic acid R78 N-term polar (charge-assisted hydrogen bond)
L-glutamic acid S157 N-term polar (hydrogen bond)
L-glutamic acid S157 N-term Van der Waals
L-glutamic acid S159 N-term polar (hydrogen bond)
L-glutamic acid S159 N-term Van der Waals
L-glutamic acid S181 N-term Van der Waals
L-glutamic acid S181 N-term polar (hydrogen bond with backbone)
L-glutamic acid T182 N-term polar (hydrogen bond)
L-glutamic acid T182 N-term polar (hydrogen bond with backbone)
L-glutamic acid T182 N-term Van der Waals
L-glutamic acid Y230 N-term hydrophobic
L-glutamic acid Y230 N-term Van der Waals
L-glutamic acid D312 N-term Van der Waals
L-glutamic acid S313 N-term Van der Waals
L-glutamic acid K317 N-term polar (charge-assisted hydrogen bond)
VU0155041 L659 3.36x36 TM3 hydrophobic
VU0155041 C746 45.50x50 ECL2 polar (hydrogen bond with backbone)
VU0155041 C746 45.50x50 ECL2 Van der Waals
VU0155041 I748 45.52x52 ECL2 polar (hydrogen bond with backbone)
VU0155041 I748 45.52x52 ECL2 Van der Waals
VU0155041 D750 5.37x37 TM5 polar (charge-assisted hydrogen bond)
VU0155041 L753 5.40x40 TM5 hydrophobic
VU0155041 L753 5.40x40 TM5 Van der Waals
VU0155041 F805 6.57x57 TM6 hydrophobic
VU0155041 F805 6.57x57 TM6 Van der Waals
VU0155041 T819 7.29x30 TM7 Van der Waals
VU0155041 L822 7.32x33 TM7 hydrophobic
VU0155041 L822 7.32x33 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

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NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 T N D P I V K A S ICL1ECL1 A E P ECL1ICL2 V S A P R F I ICL2ECL2 P S H S V V D F Q D Q R T L D P R F A R G V L K C D I ECL2ICL3 R G V P E T F N E ICL3ECL3 A D ECL3N-term M P G K R G L G W W W A R L P L C L L L S L Y G P W M P S S L G K P K G H P H M N S I R I D G D I T L G G L F P V H G R G S E G K P C G E L K K E K G I H R L E A M L F A L D R I N N D P D L L P N I T L G A R I L D T C S R D T H A L E Q S L T F V Q A L I E K D G T E V R C G S G G P P I I T K P E R V V G V I G A S G S S V S I M V A N I L R L F K I P Q I S Y A S T A P D L S D N S R Y D F F S R V V P S D T Y Q A Q A M V D I V R A L K W N Y V S T V A S E G S Y G E S G V E A F I Q K S R E D G G V C I A Q S V K I P R E P K A G E F D K I I R R L L E T S N A R A V I I F A N E D D I R R V L E A A R R A N Q T G H F F W M G S D S W G S K I A P V L H L E E V A E G A V T I L P K R M S V R G F D R Y F S S R T L D N N R R N I W F A E F W E D N F H C K L S R H A L K K G S H V K K C T N R E R I G Q D S A Y E Q E G K V Q F V I D A V Y A M G H A L H A M H R D L C P G R V G L C P R M D P V D G T Q L L K Y I R N V N F S G I A G N P V T F N E N G D A P G R Y D I Y Q Y Q L R N D S A E Y K V I G S W T D H L H L R I E R M H W P G S G Q Q L P R S I C S L P C Q P G E R K K T V K G M P C C W H C E P C T G Y Q Y Q V D R Y T C K T C P Y D M R P T E N R T G C R P I P I I K L E W G S N-termC-term K A V V T A A T M S N K F T Q K G N F R P N G E A K S E L C E N L E A P A L A T K Q T Y V T Y T N H A I C-term P W A V L P L F L A V V G I A A T L F V V I T F V R Y G R E L S Y V L L A G I F L C Y A T T F L M I D L G T C S L R R I F L G L G M S I S Y A A L L T K T N R I Y R I F E Q G K R S S P A S Q L A I T F S L I S L Q L L G I C V W F V V D S D L S L I C L L G Y S M L L M V T C T V Y A I K T A K P I G F T M Y T T C I V W L A F I P I F F G T S Q S K L Y I Q T T T L T V S V S L S A S V S L G M L Y M P K V Y I I L F H P E Q R K R N V P K S L
Helix box plot — Download: PNG | SVG L T A A I G V V A L F L P L V A W P 1 Y V L L A G I F L C Y A T T F L M I 2 T L L A A Y S I S M G L G L F I R R L S 3 Q L A I T F S L I S L Q L L G I C V W F 4 A Y V T C T V M L L M S Y G L L C I L S 5 G F T M Y T T C I V W L A F I P I F F G 6 G L S V S A S L S V S V T L T T T Q I Y 7

GPCRdb(A)
GPCRdb(C)
mGlu4 receptor
TM3
3x32 3.36x36 L659
ECL2
45x50 45.50x50 C746
45x52 45.52x52 I748
TM5
5x37 5.37x37 D750
5x40 5.40x40 L753
TM6
6x55 6.57x57 F805
TM7
7x35 7.29x30 T819
7x38 7.32x33 L822