Ligands
Function
Agonist
Agonist
Reference
| Ligand | Amino Acid | Generic Number | Segment | Interaction Type |
|---|---|---|---|---|
| LYSOPHOSPHATIDIC ACID | K128 | 3.26x26 | TM3 | polar (charge-charge) |
| LYSOPHOSPHATIDIC ACID | G131 | 3.29x29 | TM3 | Van der Waals |
| LYSOPHOSPHATIDIC ACID | T132 | 3.30x30 | TM3 | hydrophobic |
| L-serine | Y135 | 3.33x33 | TM3 | polar (hydrogen bond) |
| LYSOPHOSPHATIDIC ACID | Y135 | 3.33x33 | TM3 | hydrophobic |
| LYSOPHOSPHATIDIC ACID | M136 | 3.34x34 | TM3 | Van der Waals |
| LYSOPHOSPHATIDIC ACID | Y139 | 3.37x37 | TM3 | Van der Waals |
| LYSOPHOSPHATIDIC ACID | I143 | 3.41x41 | TM3 | Van der Waals |
| LYSOPHOSPHATIDIC ACID | L181 | 4.52x52 | TM4 | Van der Waals |
| LYSOPHOSPHATIDIC ACID | A182 | 4.53x53 | TM4 | hydrophobic |
| LYSOPHOSPHATIDIC ACID | G185 | 4.56x56 | TM4 | Van der Waals |
| LYSOPHOSPHATIDIC ACID | F186 | 4.57x57 | TM4 | Van der Waals |
| LYSOPHOSPHATIDIC ACID | M189 | 4.60x60 | TM4 | hydrophobic |
| LYSOPHOSPHATIDIC ACID | F205 | 45.51x51 | ECL2 | Van der Waals |
| L-serine | F205 | 45.51x51 | ECL2 | Van der Waals |
| L-serine | H206 | 45.52x52 | ECL2 | Van der Waals |
| LYSOPHOSPHATIDIC ACID | R208 | ECL2 | polar (charge-charge) | |
| LYSOPHOSPHATIDIC ACID | K210 | ECL2 | Van der Waals | |
| LYSOPHOSPHATIDIC ACID | F219 | 5.39x39 | TM5 | Van der Waals |
| LYSOPHOSPHATIDIC ACID | N220 | 5.40x40 | TM5 | polar (hydrogen bond) |
| LYSOPHOSPHATIDIC ACID | I222 | 5.42x42 | TM5 | Van der Waals |
| LYSOPHOSPHATIDIC ACID | L223 | 5.43x43 | TM5 | hydrophobic |
| LYSOPHOSPHATIDIC ACID | M226 | 5.46x46 | TM5 | hydrophobic |
| LYSOPHOSPHATIDIC ACID | L229 | 5.49x49 | TM5 | Van der Waals |
| L-serine | R286 | 6.55x55 | TM6 | polar (hydrogen bond) |
| L-serine | R286 | 6.55x55 | TM6 | polar (charge-charge) |
| L-serine | Y289 | 6.58x58 | TM6 | Van der Waals |
| L-serine | N309 | 7.35x34 | TM7 | polar (hydrogen bond) |
| L-serine | E310 | 7.36x35 | TM7 | polar (charge-charge) |
, 'snake_8WRB.png', {scale: 3});){kind=link}
, 'helixbox8WRB.png', {scale: 3});){kind=link}
|
GPCRdb(A)
|
GPCRdb(A)
|
GPR34
|
|---|---|---|
| TM3 | ||
| 3x26 | 3.26x26 | K128 |
| 3x29 | 3.29x29 | G131 |
| 3x30 | 3.30x30 | T132 |
| 3x33 | 3.33x33 | Y135 |
| 3x34 | 3.34x34 | M136 |
| 3x37 | 3.37x37 | Y139 |
| 3x41 | 3.41x41 | I143 |
| TM4 | ||
| 4x52 | 4.52x52 | L181 |
| 4x53 | 4.53x53 | A182 |
| 4x56 | 4.56x56 | G185 |
| 4x57 | 4.57x57 | F186 |
| 4x60 | 4.60x60 | M189 |
| ECL2 | ||
| 45x51 | 45.51x51 | F205 |
| 45x52 | 45.52x52 | H206 |
| TM5 | ||
| 5x39 | 5.39x39 | F219 |
| 5x40 | 5.40x40 | N220 |
| 5x42 | 5.42x42 | I222 |
| 5x43 | 5.43x43 | L223 |
| 5x46 | 5.46x46 | M226 |
| 5x49 | 5.49x49 | L229 |
| TM6 | ||
| 6x55 | 6.55x55 | R286 |
| 6x58 | 6.58x58 | Y289 |
| TM7 | ||
| 7x34 | 7.35x34 | N309 |
| 7x35 | 7.36x35 | E310 |