Structure information

MCH2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8WST

SPECIES

Homo sapiens

RESOLUTION

2.400

PREFERRED CHAIN

R

REFERENCE

10.1038/S41421-024-00679-8

PUBLICATION DATE

June 19, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
pro-MCH H82 2.53x53 TM2 polar (hydrogen bond)
pro-MCH Q92 2.63x63 TM2 Van der Waals
pro-MCH W93 2.64x64 TM2 Van der Waals
pro-MCH W93 2.64x64 TM2 polar (hydrogen bond)
pro-MCH G96 2.67x67 TM2 polar (hydrogen bond with backbone)
pro-MCH G96 2.67x67 TM2 Van der Waals
pro-MCH G97 ECL1 Van der Waals
pro-MCH D113 3.32x32 TM3 polar (charge-assisted hydrogen bond)
pro-MCH Q117 3.36x36 TM3 polar (hydrogen bond)
pro-MCH F177 ECL2 Van der Waals
pro-MCH F177 ECL2 hydrophobic
pro-MCH S183 ECL2 Van der Waals
pro-MCH C184 45.50x50 ECL2 Van der Waals
pro-MCH C184 45.50x50 ECL2 hydrophobic
pro-MCH A185 45.51x51 ECL2 hydrophobic
pro-MCH A185 45.51x51 ECL2 Van der Waals
pro-MCH F186 45.52x52 ECL2 Van der Waals
pro-MCH F186 45.52x52 ECL2 polar (hydrogen bond with backbone)
pro-MCH L188 ECL2 hydrophobic
pro-MCH L188 ECL2 Van der Waals
pro-MCH T189 ECL2 Van der Waals
pro-MCH P191 5.32x33 TM5 hydrophobic
pro-MCH P191 5.32x33 TM5 Van der Waals
pro-MCH V194 5.35x36 TM5 Van der Waals
pro-MCH V194 5.35x36 TM5 hydrophobic
pro-MCH Y197 5.38x39 TM5 hydrophobic
pro-MCH Y267 6.51x51 TM6 Van der Waals
pro-MCH Q271 6.55x55 TM6 polar (hydrogen bond)
pro-MCH N274 6.58x58 TM6 polar (hydrogen bond)
pro-MCH N274 6.58x58 TM6 Van der Waals
pro-MCH Q279 ECL3 Van der Waals
pro-MCH P280 ECL3 Van der Waals
pro-MCH P280 ECL3 hydrophobic
pro-MCH F284 7.31x30 TM7 Van der Waals
pro-MCH Y285 7.32x31 TM7 Van der Waals
pro-MCH Y285 7.32x31 TM7 polar (hydrogen bond)
pro-MCH Y288 7.35x34 TM7 polar (hydrogen bond)
pro-MCH I292 7.39x38 TM7 hydrophobic
pro-MCH I292 7.39x38 TM7 Van der Waals
pro-MCH S295 7.42x41 TM7 polar (hydrogen bond)
pro-MCH Y296 7.43x42 TM7 polar (hydrogen bond)

Ligands

pro-MCH

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Residue Diagrams

I N G V L G T S C I I G I M S P L I V T 1 C N L A V A D L V H I V G M P F L I H Q 2 V T M I A S C A F Q N C T D L S T I I T 3 T I R I N L G L W A A S F I L A L P V 4 Y C V L I L P L P F F F T T I T L Y L T Y 5 L V L V V V F I L S A A P Y H V I Q L V 6 F P N I S S S A Y S L C I S L Y Y G V 7
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ICL1 R K K ICL1ECL1 G E W V F ECL1ICL2 P F R L T R W R ICL2ECL2 K V I K F K D G V E S C A F D L T ECL2ICL3 D A R C C ICL3ECL3 E Q P ECL3N-term M N P F H A S C W N T S A E L L N K S W N K E F A Y Q T A S N-termC-term R A T E K E I N N M G N T L K S H F C-term V V D T V I L P S M I G I I C S T G L V G N I L I V F T I I R S T V P D I Y I C N L A V A D L V H I V G M P F L I H Q W A R G G G P L C T I I T S L D T C N Q F A C S A I M T V M S V D R Y F A L V Q T R Y K T I R I N L G L W A A S F I L A L P V W V Y S S P D D V L W Y T L Y L T I T T F F F P L P L I L V C Y I L I L C Y T W E M Y Q Q N K N P S V P K Q R V M K L T K M V L V L V V V F I L S A A P Y H V I Q L V N L Q M T L A F Y V G Y Y L S I C L S Y A S S S I N P F L Y I L L S G N L P Q F Q K R I Q R
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Residue Table


GPCRdb(A)
GPCRdb(A)
MCH2 receptor
TM2
2x53 2.53x53 H82
2x63 2.63x63 Q92
2x64 2.64x64 W93
2x67 2.67x67 G96
TM3
3x32 3.32x32 D113
3x36 3.36x36 Q117
ECL2
45x50 45.50x50 C184
45x51 45.51x51 A185
45x52 45.52x52 F186
TM5
5x33 5.32x33 P191
5x36 5.35x36 V194
5x39 5.38x39 Y197
TM6
6x51 6.51x51 Y267
6x55 6.55x55 Q271
6x58 6.58x58 N274
TM7
7x30 7.31x30 F284
7x31 7.32x31 Y285
7x34 7.35x34 Y288
7x38 7.39x38 I292
7x41 7.42x41 S295
7x42 7.43x42 Y296