PDB
8WW2
Resolution
2.8 Å
Released
Feb. 14, 2024
Receptor
GPR3
Class
A
Species
Homo sapiens
Ligand
Function
oleic acid
Agonist
Reference
10.1038/S41422-024-00932-5

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Ligand Amino Acid Generic Number Segment Interaction Type
oleic acid L47 1.39x39 TM1 Van der Waals
oleic acid H96 ECL1 polar (charge-charge)
oleic acid L116 3.32x32 TM3 hydrophobic
oleic acid A117 3.33x33 TM3 Van der Waals
oleic acid F120 3.36x36 TM3 hydrophobic
oleic acid T121 3.37x37 TM3 hydrophobic
oleic acid I124 3.40x40 TM3 hydrophobic
oleic acid V187 ECL2 Van der Waals
oleic acid L198 5.43x43 TM5 hydrophobic
oleic acid A201 5.46x46 TM5 hydrophobic
oleic acid F202 5.47x47 TM5 Van der Waals
oleic acid W260 6.48x48 TM6 hydrophobic
oleic acid F263 6.51x51 TM6 Van der Waals
oleic acid L283 7.39x38 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 P A F R ICL1ECL1 C I G ECL1ICL2 A L T Y Y ICL2ECL2 V L A W N C L D G L T T C G V V Y P L ECL2ICL3 H L ICL3ECL3 D A H S ECL3N-term M M W G A G S P L A W L S A G S G N V N V S S V G P A E G P T G P A A P L P S P N-termC-term C C S S S K I P F R S R S P S D V C-term K A W D V V L C I S G T L V S C E N A L V V A I I V G T A P M F L L V G S L A V A D L L A G L G L V L H F A A V F S A E M S L V L V G V L A M A F T A S I G S L L A I T V D R Y L S L Y N S E T T V T R T Y V M L A L V W G G A L G L G L L P S K N H L V V L A I A F F M V F G I M L Q L Y A Q I C R I V C R H A Q Q I A L Q R L P A S H Y V A T R K G I A T L A V V L G A F A A C W L P F T V Y C L L G P P L Y T Y L T L L P A T Y N S M I N P I I Y A F R N Q D L W A V Q K V V C C
Helix box plot — Download: PNG | SVG A N E C S V L T G S I C L V V D W A K 1 G S L A V A D L L A G L G L V L H F A A 2 A L L S G I S A T F A M A L V G V L V L 3 T Y V M L A L V W G G A L G L G L L P 4 Y L Q L M I G F V M F F A I A L V V L H 5 A V V L G A F A A C W L P F T V Y C L L 6 I P N I M S N Y T A P L L T L Y T Y L 7

GPCRdb(A)
GPCRdb(A)
GPR3
TM1
1x39 1.39x39 L47
TM3
3x32 3.32x32 L116
3x33 3.33x33 A117
3x36 3.36x36 F120
3x37 3.37x37 T121
3x40 3.40x40 I124
TM5
5x43 5.43x43 L198
5x46 5.46x46 A201
5x47 5.47x47 F202
TM6
6x48 6.48x48 W260
6x51 6.51x51 F263
TM7
7x38 7.39x38 L283