PDB
8X3L
Resolution
3.1 Å
Released
Nov. 20, 2024
Receptor
CB2
Class
A
Species
Homo sapiens
Ligand
CHEMBL5422946
Function
Agonist
Reference
10.1073/PNAS.2401091121

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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL5422946 F87 2.57x57 TM2 hydrophobic
CHEMBL5422946 I110 3.29x29 TM3 hydrophobic
CHEMBL5422946 V113 3.32x32 TM3 hydrophobic
CHEMBL5422946 F117 3.36x36 TM3 hydrophobic
CHEMBL5422946 F183 ECL2 hydrophobic
CHEMBL5422946 W194 5.43x43 TM5 hydrophobic
CHEMBL5422946 S285 7.39x38 TM7 polar (hydrogen bond)
CHEMBL5422946 S285 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 H Q L R R ICL1ECL1 F H G V D ECL1ICL2 P P S Y K A L L ICL2ECL2 W T C C P R P C S E L F P L I ECL2ICL3 H Q D R Q V P G M A R M ICL3ECL3 T L ECL3N-term M E E C W V T E I A N G S K D G L D S N P M K D Y M I L N-termC-term C V R G L G S E A K E E A P R S S V T E T E A D G K I T P W P D S R D L D L S D C C-term S G P Q K T A V A V L C T L L G L L S A L E N V A V L Y L I L S S K P S Y L F I G S L A G A D F L A S V V F A C S F V N F H V S K A V F L L K I G S V T M T F T A S V G S L L L T A I D R Y L C L R Y T R G R A L V T L G I M W V L S A L V S Y L P L M G P N D Y L L S W L L F I A F L F S G I I Y T Y G H V L W K A H Q H V A S L S G R L D V R L A K T L G L V L A V L L I C W F P V L A L M A H S L A T S D Q V K K A F A F C S M L C L I N S M V N P V I Y A L R S G E A H H W K K I R S S C L A H
Helix box plot — Download: PNG | SVG V N E L A S L L G L L T C L V A V A T K 1 G S L A G A D F L A S V V F A C S F V N 2 L L L S G V S A T F T M T V S G I K L L 3 A L V T L G I M W V L S A L V S Y L P L 4 Y T Y I I G S F L F A I F L L W S L L Y 5 G L V L A V L L I C W F P V L A L M A H 6 V P N V M S N I L C L M S C F A F A K 7

GPCRdb(A)
GPCRdb(A)
CB2 receptor
TM2
2x57 2.57x57 F87
TM3
3x29 3.29x29 I110
3x32 3.32x32 V113
3x36 3.36x36 F117
TM5
5x43 5.43x43 W194
TM7
7x38 7.39x38 S285