PDB
8X63
Resolution
3.2 Å
Released
Jan. 17, 2024
Receptor
H1
Class
A
Species
Homo sapiens
Ligand
Function
mepyramine
Inverse agonist
Reference
10.1038/S41467-023-44477-4

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Ligand Amino Acid Generic Number Segment Interaction Type
mepyramine D107 3.32x32 TM3 polar (charge-charge)
mepyramine Y108 3.33x33 TM3 aromatic (edge-to-face)
mepyramine S111 3.36x36 TM3 Van der Waals
mepyramine T112 3.37x37 TM3 Van der Waals
mepyramine I115 3.40x40 TM3 Van der Waals
mepyramine W158 4.56x57 TM4 aromatic (edge-to-face)
mepyramine T194 5.42x43 TM5 hydrophobic
mepyramine A195 5.43x44 TM5 hydrophobic
mepyramine N198 5.46x461 TM5 Van der Waals
mepyramine F424 6.44x44 TM6 Van der Waals
mepyramine W428 6.48x48 TM6 aromatic (edge-to-face)
mepyramine W428 6.48x48 TM6 hydrophobic
mepyramine Y431 6.51x51 TM6 polar (hydrogen bond)
mepyramine F432 6.52x52 TM6 hydrophobic
mepyramine F432 6.52x52 TM6 aromatic (edge-to-face)
mepyramine F435 6.55x55 TM6 hydrophobic
mepyramine I454 7.39x38 TM7 Van der Waals
mepyramine Y458 7.43x42 TM7 Van der Waals

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ICL1 R K L H ICL1ECL1 S K W S L ECL1ICL2 P L R Y L K Y R ICL2ECL2 W N H F M Q Q T S V R R E D K C E T D F Y D ECL2ICL3 R S L P S F S E I K L R P E N P K G D A K K P G K E S P W E V L K R K P K D A G G G S V L K S P S Q T P K E M K S P V V F S Q E D D R E V D K L Y C F P L D I V H M Q A A A E G S S R D Y V A V N R S H G Q L K T D E Q G L N T H G A S E I S E D Q M L G D S Q S F S R T D S D T T T E T A P G K G K L R S G S N T G L D Y I K F T W K R L R S H S R Q Y V S ICL3ECL3 K N C C ECL3N-term M S L P N S S C L L E D K M C E G N K T T M A S P Q L M N-termC-term I R S C-term P L V V V L S T I C L V T V G L N L L V L Y A V R S E T V G N L Y I V S L S V A D L I V G A V V M P M N I L Y L L M G R P L C L F W L S M D Y V A S T A S I F S V F I L C I D R Y R S V Q Q T K T R A S A T I L G A W F L S F L W V I P I L G V T W F K V M T A I I N F Y L P T L L M L W F Y A K I Y K A V R Q H C Q H R E L I N G L H M N R E R K A A K Q L G F I M A A F I L C W I P Y F I F F M V I A F C N E H L H M F T I W L G Y I N S T L N P L I Y P L C N E N F K R F K K T I L H
Helix box plot — Download: PNG | SVG L N L G V T V L C I T S L V V V L P 1 V S L S V A D L I V G V A V M P M N I L Y 2 I F V S F I S A T S A V Y D M S L W F L 3 A S A T I L G A W F L S F L W V I P I 4 Y F W L M L L T P L Y F N I I A T M V K F 5 G F I M A A F I L C W I P Y F I F F M V 6 L P N L T S N I Y G L W I T F M H L H 7

GPCRdb(A)
GPCRdb(A)
H1 receptor
TM3
3x32 3.32x32 D107
3x33 3.33x33 Y108
3x36 3.36x36 S111
3x37 3.37x37 T112
3x40 3.40x40 I115
TM4
4x57 4.56x57 W158
TM5
5x43 5.42x43 T194
5x44 5.43x44 A195
5x461 5.46x461 N198
TM6
6x44 6.44x44 F424
6x48 6.48x48 W428
6x51 6.51x51 Y431
6x52 6.52x52 F432
6x55 6.55x55 F435
TM7
7x38 7.39x38 I454
7x42 7.43x42 Y458