Structure information

IP receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8X7A

SPECIES

Homo sapiens

RESOLUTION

2.560

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIADV.ADK5184

PUBLICATION DATE

March 6, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
treprostinil S20 1.39x39 TM1 polar (hydrogen bond)
treprostinil M23 1.42x42 TM1 Van der Waals
treprostinil F24 1.43x43 TM1 Van der Waals
treprostinil G63 2.53x53 TM2 polar (hydrogen bond)
treprostinil G63 2.53x53 TM2 polar (hydrogen bond with backbone)
treprostinil T64 2.54x54 TM2 polar (hydrogen bond)
treprostinil L67 2.57x57 TM2 Van der Waals
treprostinil L67 2.57x57 TM2 polar (hydrogen bond with backbone)
treprostinil S68 2.58x58 TM2 polar (hydrogen bond with backbone)
treprostinil S68 2.58x58 TM2 Van der Waals
treprostinil V71 2.61x61 TM2 hydrophobic
treprostinil V71 2.61x61 TM2 Van der Waals
treprostinil Y75 2.65x65 TM2 polar (hydrogen bond)
treprostinil Y75 2.65x65 TM2 polar (hydrogen bond)
treprostinil F95 3.28x28 TM3 Van der Waals
treprostinil F95 3.28x28 TM3 hydrophobic
treprostinil M99 3.32x32 TM3 polar (hydrogen bond with backbone)
treprostinil M99 3.32x32 TM3 Van der Waals
treprostinil F102 3.35x35 TM3 Van der Waals
treprostinil G103 3.36x36 TM3 polar (hydrogen bond with backbone)
treprostinil G103 3.36x36 TM3 Van der Waals
treprostinil P166 ECL2 polar (hydrogen bond)
treprostinil S168 ECL2 polar (hydrogen bond)
treprostinil S168 ECL2 polar (hydrogen bond)
treprostinil W169 ECL2 polar (hydrogen bond with backbone)
treprostinil W169 ECL2 Van der Waals
treprostinil F278 7.39x38 TM7 polar (hydrogen bond)
treprostinil R279 7.40x39 TM7 polar (charge-assisted hydrogen bond)
treprostinil Y281 7.42x41 TM7 polar (hydrogen bond with backbone)
treprostinil Y281 7.42x41 TM7 Van der Waals
treprostinil A282 7.43x42 TM7 polar (hydrogen bond)
treprostinil A282 7.43x42 TM7 polar (hydrogen bond with backbone)
treprostinil P285 7.46x46 TM7 polar (hydrogen bond)

Ligands

treprostinil

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Residue Diagrams

G N G V V G A V F M L T S T A P 1 T G L A A T D L L G T S F L S P A V F V 2 A F L I L M S A L G F F T M A F A F A D 3 A R L A L P A I Y A F C V L F C A L P L 4 S G N C L F I A A V L L A V L G A Y A L 5 A L M T V V M A V C S L P L T I R C F T 6 W P D L I P N F A Y F R F A L L D 7
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ICL1 R P A R P ICL1ECL1 S S L L G L A R G G ECL1ICL2 P Y L Y A Q L D ICL2ECL2 L G Q H Q Q Y C P G S W C F L R M R W A ECL2ICL3 G S L G P R P R T G E ICL3ECL3 P D S S S E M G ECL3N-term M A D S C R N L T Y V R G S V G N-termC-term P A H G D S Q T P L S Q L A S G R R D P R A P S A P V G K E G S C V P L S A W G E G Q V E P L P P T Q Q S S G S A V G T S S K A E A S V A C S L C C-term P A T S T L M F V A G V V G N G L A L G I L S A R S A F A V L V T G L A A T D L L G T S F L S P A V F V A Y A R N P A L C D A F A F A M T F F G L A S M L I L F A M A V E R C L A L S H G P R C A R L A L P A I Y A F C V L F C A L P L L G Q P G G A A F S L A Y A G L V A L L V A A I F L C N G S V T L S L C R M Y R Q Q K R H Q D E V D H L I L L A L M T V V M A V C S L P L T I R C F T Q A V A D L L A F R F Y A F N P I L D P W V F I L F R K A L K L L C L V F Q R W V C C G
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Residue Table


GPCRdb(A)
GPCRdb(A)
IP receptor
TM1
1x39 1.39x39 S20
1x42 1.42x42 M23
1x43 1.43x43 F24
TM2
2x53 2.53x53 G63
2x54 2.54x54 T64
2x57 2.57x57 L67
2x58 2.58x58 S68
2x61 2.61x61 V71
2x65 2.65x65 Y75
TM3
3x28 3.28x28 F95
3x32 3.32x32 M99
3x35 3.35x35 F102
3x36 3.36x36 G103
TM7
7x38 7.39x38 F278
7x39 7.40x39 R279
7x41 7.42x41 Y281
7x42 7.43x42 A282
7x46 7.46x46 P285