PDB
8X8L
Resolution
2.7 Å
Released
June 12, 2024
Receptor
SST5
Class
A
Species
Homo sapiens
Ligand
Function
Cortistatin
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
Cortistatin Y89 2.53x53 TM2 Van der Waals
Cortistatin L96 2.60x60 TM2 hydrophobic
Cortistatin Q99 2.63x63 TM2 Van der Waals
Cortistatin N100 2.64x64 TM2 Van der Waals
Cortistatin S103 ECL1 Van der Waals
Cortistatin D119 3.32x32 TM3 polar (charge-charge)
Cortistatin Q123 3.36x36 TM3 Van der Waals
Cortistatin T185 ECL2 polar (hydrogen bond)
Cortistatin C186 45.50x50 ECL2 polar (hydrogen bond with backbone)
Cortistatin N187 45.51x51 ECL2 polar (hydrogen bond)
Cortistatin A188 45.52x52 ECL2 hydrophobic
Cortistatin W190 ECL2 hydrophobic
Cortistatin G198 5.35x36 TM5 Van der Waals
Cortistatin F201 5.38x39 TM5 hydrophobic
Cortistatin I202 5.39x40 TM5 hydrophobic
Cortistatin T205 5.42x43 TM5 hydrophobic
Cortistatin F264 6.51x51 TM6 hydrophobic
Cortistatin F264 6.51x51 TM6 aromatic (edge-to-face)
Cortistatin F265 6.52x52 TM6 Van der Waals
Cortistatin N268 6.55x55 TM6 Van der Waals
Cortistatin N271 6.58x58 TM6 Van der Waals
Cortistatin E279 ECL3 hydrophobic
Cortistatin A283 7.32x31 TM7 hydrophobic
Cortistatin Y286 7.35x34 TM7 hydrophobic
Cortistatin F287 7.36x35 TM7 Van der Waals
Cortistatin V290 7.39x38 TM7 hydrophobic
Cortistatin Y294 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 A K M K ICL1ECL1 S F W P F ECL1ICL2 P L S S A R W R ICL2ECL2 D V Q E G G T C N A S W P E ECL2ICL3 G C V R ICL3ECL3 A L P Q E P A ECL3N-term M E P L F P A S T P S W N A S S P G A A S G G G D N R T L V G P A P S A N-termC-term L R K G S G A K D A D A T E P R P D R I R Q Q Q E A T P P A H R A A A N G L M Q T S K L C-term G A R A V L V P V L Y L L V C A A G L G G N T L V I Y V V L R F T V T N I Y I L N L A V A D V L Y M L G L P F L A T Q N A A G P V L C R L V M T L D G V N Q F T S V F C L T V M S V D R Y L A V V H R P R V A K L A S A A A W V L S L C M S L P L L V F A P V G L W G A V F I I Y T A V L G F F A P L L V I C L C Y L L I V V K V R A A G V R V R R S E R K V T R M V L V V V L V F A G C W L P F F T V N I V N L A V S A G L Y F F V V I L S Y A N S C A N P V L Y G F L S D N F Q K F R Q S V L C
Helix box plot — Download: PNG | SVG T N G G L G A A C V L L Y L V P V L V A 1 L N L A V A D V L Y M L G L P F L A T Q 2 V T L C F V S T F Q N V G D L T M V L R 3 A K L A S A A A W V L S L C M S L P L 4 Y C L C I V L L P A F F G L V A T Y I I F 5 L V V V L V F A G C W L P F F T V N I V 6 V P N A C S N A Y S L I V V F F Y L G 7

GPCRdb(A)
GPCRdb(A)
SST5 receptor
TM2
2x53 2.53x53 Y89
2x60 2.60x60 L96
2x63 2.63x63 Q99
2x64 2.64x64 N100
TM3
3x32 3.32x32 D119
3x36 3.36x36 Q123
ECL2
45x50 45.50x50 C186
45x51 45.51x51 N187
45x52 45.52x52 A188
TM5
5x36 5.35x36 G198
5x39 5.38x39 F201
5x40 5.39x40 I202
5x43 5.42x43 T205
TM6
6x51 6.51x51 F264
6x52 6.52x52 F265
6x55 6.55x55 N268
6x58 6.58x58 N271
TM7
7x31 7.32x31 A283
7x34 7.35x34 Y286
7x35 7.36x35 F287
7x38 7.39x38 V290
7x42 7.43x42 Y294