PDB
8XBG
Resolution
3.4 Å
Released
May 15, 2024
Receptor
GPR34
Class
A
Species
Homo sapiens
Ligand
CHEMBL4782438
Function
Agonist
Reference
10.1038/S41467-024-45046-Z

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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL4782438 Y135 3.33x33 TM3 polar (hydrogen bond)
CHEMBL4782438 Y135 3.33x33 TM3 Van der Waals
CHEMBL4782438 M136 3.34x34 TM3 hydrophobic
CHEMBL4782438 M136 3.34x34 TM3 Van der Waals
CHEMBL4782438 A182 4.53x53 TM4 hydrophobic
CHEMBL4782438 A182 4.53x53 TM4 Van der Waals
CHEMBL4782438 F186 4.57x57 TM4 hydrophobic
CHEMBL4782438 M189 4.60x60 TM4 Van der Waals
CHEMBL4782438 M189 4.60x60 TM4 hydrophobic
CHEMBL4782438 T193 4.64x64 TM4 Van der Waals
CHEMBL4782438 F205 45.51x51 ECL2 polar (hydrogen bond with backbone)
CHEMBL4782438 F205 45.51x51 ECL2 Van der Waals
CHEMBL4782438 K210 ECL2 Van der Waals
CHEMBL4782438 F219 5.39x39 TM5 hydrophobic
CHEMBL4782438 F219 5.39x39 TM5 Van der Waals
CHEMBL4782438 N220 5.40x40 TM5 Van der Waals
CHEMBL4782438 N220 5.40x40 TM5 polar (hydrogen bond)
CHEMBL4782438 L223 5.43x43 TM5 hydrophobic
CHEMBL4782438 L223 5.43x43 TM5 Van der Waals
CHEMBL4782438 R286 6.55x55 TM6 polar (charge-assisted hydrogen bond)
CHEMBL4782438 Y289 6.58x58 TM6 polar (hydrogen bond)
CHEMBL4782438 Y289 6.58x58 TM6 Van der Waals
CHEMBL4782438 N309 7.35x34 TM7 polar (hydrogen bond)
CHEMBL4782438 N309 7.35x34 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R K R ICL1ECL1 N K W T L ECL1ICL2 I Q Q R K A I T T ICL2ECL2 G H N S T M C F H Y R D K H N A ECL2ICL3 R R S K F P N ICL3ECL3 Q L N V S ECL3N-term M R S H T I T M T T T S V S S W P Y S S H R M R F I T N H S D Q P P Q N F S A T P N V T T C P M D E K N-termC-term G E P S R S E S T S E F K P G Y S L H D T S V A V K I Q S S S K S T C-term L L S T V L T T S Y S V I F I V G L V G N I I A L Y V F L G I H N S I Q I Y L L N V A I A D L L L I F C L P F R I M Y H I N Q G V I L C K V V G T L F Y M N M Y I S I I L L G F I S L D R Y I K I N R S K Q S I Y V C C I V W M L A L G G F L T M I I L T L K K G K G E A I F N F I L V V M F W L I F L L I I L S Y I K I G K N L L R I S K S G K Y A T T A R N S F I V L I I F T I C F V P Y H A F R F I Y I S S S C Y W K E I V H K T N E I M L V L S S F N S C L D P V M Y F L M S S N M C Q R F Q I R K I L L F R
Helix box plot — Download: PNG | SVG I N G V L G V I F I V S Y S T T L V T S 1 L N V A I A D L L L I F C L P F R I M Y 2 F G L L I I S I Y M N M Y F L T G V V K 3 S I Y V C C I V W M L A L G G F L T M I 4 Y S L I I L L F I L W F M V V L I F N F 5 S F I V L I I F I T C F V P Y H A F R F I 6 V P D L C S N F S S L V L M I E N T K 7

GPCRdb(A)
GPCRdb(A)
GPR34
TM3
3x33 3.33x33 Y135
3x34 3.34x34 M136
TM4
4x53 4.53x53 A182
4x57 4.57x57 F186
4x60 4.60x60 M189
4x64 4.64x64 T193
ECL2
45x51 45.51x51 F205
TM5
5x39 5.39x39 F219
5x40 5.40x40 N220
5x43 5.43x43 L223
TM6
6x55 6.55x55 R286
6x58 6.58x58 Y289
TM7
7x34 7.35x34 N309