PDB
8XGM
Resolution
3.3 Å
Released
Aug. 21, 2024
Receptor
chemerin 2
Class
A
Species
Homo sapiens
Ligand
Function
Chemerin
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
Chemerin Y15 N-term polar (hydrogen bond)
Chemerin Y15 N-term hydrophobic
Chemerin S16 N-term Van der Waals
Chemerin Y17 N-term aromatic (pi-cation)
Chemerin Y17 N-term hydrophobic
Chemerin D18 N-term Van der Waals
Chemerin L19 N-term Van der Waals
Chemerin D20 N-term Van der Waals
Chemerin Y21 N-term hydrophobic
Chemerin Y22 N-term aromatic (edge-to-face)
Chemerin Y22 N-term hydrophobic
Chemerin S23 N-term Van der Waals
Chemerin L24 N-term hydrophobic
Chemerin E25 N-term polar (charge-charge)
Chemerin S26 N-term Van der Waals
Chemerin L28 N-term hydrophobic
Chemerin E29 N-term Van der Waals
Chemerin F86 2.53x53 TM2 hydrophobic
Chemerin Y93 2.60x60 TM2 polar (hydrogen bond)
Chemerin Y96 2.63x63 TM2 polar (hydrogen bond)
Chemerin F101 ECL1 aromatic (edge-to-face)
Chemerin F101 ECL1 hydrophobic
Chemerin S114 3.29x29 TM3 Van der Waals
Chemerin A117 3.32x32 TM3 hydrophobic
Chemerin Q118 3.33x33 TM3 Van der Waals
Chemerin M121 3.36x36 TM3 Van der Waals
Chemerin R176 4.64x64 TM4 polar (hydrogen bond)
Chemerin R176 4.64x64 TM4 polar (charge-charge)
Chemerin V179 ECL2 hydrophobic
Chemerin F181 ECL2 aromatic (edge-to-face)
Chemerin F181 ECL2 hydrophobic
Chemerin L186 ECL2 hydrophobic
Chemerin C187 45.50x50 ECL2 Van der Waals
Chemerin Y188 45.51x51 ECL2 hydrophobic
Chemerin N189 45.52x52 ECL2 polar (hydrogen bond)
Chemerin N189 45.52x52 ECL2 polar (hydrogen bond with backbone)
Chemerin F191 ECL2 Van der Waals
Chemerin Q192 ECL2 Van der Waals
Chemerin K193 ECL2 Van der Waals
Chemerin H194 ECL2 Van der Waals
Chemerin H203 5.35x36 TM5 Van der Waals
Chemerin K210 5.42x43 TM5 polar (charge-charge)
Chemerin E269 6.58x58 TM6 polar (hydrogen bond)
Chemerin I272 6.61x61 TM6 polar (hydrogen bond with backbone)
Chemerin I272 6.61x61 TM6 hydrophobic
Chemerin N275 ECL3 Van der Waals
Chemerin S276 ECL3 Van der Waals
Chemerin Y277 ECL3 Van der Waals
Chemerin H279 7.28x27 TM7 Van der Waals
Chemerin M282 7.31x30 TM7 Van der Waals
Chemerin Q283 7.32x31 TM7 Van der Waals
Chemerin I286 7.35x34 TM7 hydrophobic
Chemerin T290 7.39x38 TM7 hydrophobic

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ICL1 K K ICL1ECL1 F H W P F ECL1ICL2 P V L S H R H R ICL2ECL2 D T V E F N N H T L C Y N N F Q K H D P D ECL2ICL3 I L I ICL3ECL3 H N S Y S ECL3N-term M E D L E E T L F E E F E N Y S Y D L D Y Y S L E S D L E E K V Q L N-termC-term A E I L K Y T L W E V S C S G T V S E Q L R N S E T K N L C L L E T A Q C-term G V V H W V S L V L Y C L A F V L G I P G N A I V I W F T G F K W T V T T L W F L N L A I A D F I F L L F L P L Y I S Y V A M N G I W L C K A N S F T A Q L N M F A S V F F L T V I S L D H Y I H L I H T L K N S L I V I I F I W L L A S L I G G P A L Y F R L T L I R H H V L T W V K F I I G Y L F P L L T M S I C Y L C L I F K V K K R S S S R H F W T I L V V V V A F V V C W T P Y H L F S I W E L T I H H H V M Q A G I P L S T G L A F L N S C L N P I L Y V L I S K K F R S F Q A R S V
Helix box plot — Download: PNG | SVG A N G P I G L V F A L C Y L V L S V W H 1 L N L A I A D F I F L L F L P L Y I S Y 2 V T L F F V S A F M N L Q A T F S N A K 3 S L I V I I F I W L L A S L I G G P A L 4 Y C I S M T L L P F L Y G I I F K V W T L 5 L V V V V A F V V C W T P Y H L F S I W 6 I P N L C S N L F A L G T S L P I G A 7

GPCRdb(A)
GPCRdb(A)
chemerin receptor 2
TM2
2x53 2.53x53 F86
2x60 2.60x60 Y93
2x63 2.63x63 Y96
TM3
3x29 3.29x29 S114
3x32 3.32x32 A117
3x33 3.33x33 Q118
3x36 3.36x36 M121
TM4
4x64 4.64x64 R176
ECL2
45x50 45.50x50 C187
45x51 45.51x51 Y188
45x52 45.52x52 N189
TM5
5x36 5.35x36 H203
5x43 5.42x43 K210
TM6
6x58 6.58x58 E269
6x61 6.61x61 I272
TM7
7x27 7.28x27 H279
7x30 7.31x30 M282
7x31 7.32x31 Q283
7x34 7.35x34 I286
7x38 7.39x38 T290