Structure information

kisspeptin receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8XGU

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

A

REFERENCE

10.1126/SCIADV.ADN7771

PUBLICATION DATE

Oct. 30, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
TAK448 C95 2.57x56 TM2 Van der Waals
TAK448 C95 2.57x56 TM2 polar (hydrogen bond)
TAK448 F98 2.60x59 TM2 Van der Waals
TAK448 T99 2.61x60 TM2 Van der Waals
TAK448 L102 ECL1 Van der Waals
TAK448 L102 ECL1 hydrophobic
TAK448 Y103 ECL1 Van der Waals
TAK448 G107 23.49x49 ECL1 Van der Waals
TAK448 V118 3.28x28 TM3 Van der Waals
TAK448 N119 3.29x29 TM3 polar (hydrogen bond)
TAK448 Q122 3.32x32 TM3 polar (hydrogen bond)
TAK448 Q123 3.33x33 TM3 Van der Waals
TAK448 Q123 3.33x33 TM3 polar (hydrogen bond)
TAK448 V126 3.36x36 TM3 Van der Waals
TAK448 V126 3.36x36 TM3 hydrophobic
TAK448 Y190 ECL2 polar (hydrogen bond)
TAK448 C191 45.50x50 ECL2 Van der Waals
TAK448 F195 ECL2 Van der Waals
TAK448 F204 5.38x39 TM5 Van der Waals
TAK448 F204 5.38x39 TM5 hydrophobic
TAK448 N208 5.42x43 TM5 Van der Waals
TAK448 I279 6.51x51 TM6 hydrophobic
TAK448 I279 6.51x51 TM6 Van der Waals
TAK448 Q280 6.52x52 TM6 Van der Waals
TAK448 F282 6.54x54 TM6 hydrophobic
TAK448 F282 6.54x54 TM6 Van der Waals
TAK448 L283 6.55x55 TM6 hydrophobic
TAK448 L283 6.55x55 TM6 Van der Waals
TAK448 Q286 6.58x58 TM6 Van der Waals
TAK448 P296 ECL3 Van der Waals
TAK448 P296 ECL3 hydrophobic
TAK448 R297 ECL3 Van der Waals
TAK448 S298 7.28x27 TM7 Van der Waals
TAK448 Y299 7.29x28 TM7 Van der Waals
TAK448 Y299 7.29x28 TM7 hydrophobic
TAK448 A301 7.31x30 TM7 Van der Waals
TAK448 Y302 7.32x31 TM7 hydrophobic
TAK448 Y302 7.32x31 TM7 Van der Waals
TAK448 K305 7.35x34 TM7 Van der Waals
TAK448 H309 7.39x38 TM7 polar (hydrogen bond)
TAK448 H309 7.39x38 TM7 Van der Waals
TAK448 Y313 7.43x42 TM7 polar (hydrogen bond)
TAK448 Y313 7.43x42 TM7 Van der Waals

Ligands

TAK448

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Residue Diagrams

S N G V L G L L M L A A F F L P V L W A 1 A N L A A T D V T F L C L C V P F T A L L 2 A T L T A C T A Q V S V Q Q I Y N V F K 3 A L A V S L S I W V G S A A V S A P V 4 Y C A C T A L L P L L Y L A L L N Y L A F 5 A A V V L L F A A C W G P I Q L F L V L 6 L P N L A S N S Y S M C H A W T K L A 7
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ICL1 K P M R ICL1ECL1 P L P G W V L ECL1ICL2 P L R A L H R R ICL2ECL2 R L S P G P R A Y C S E A F P ECL2ECL3 P A G S W H P R ECL3N-term M H T V A T S G P N A S W G A P A N A S G C P G C G A N A S D G P V P S P R N-termC-term C A P R R P R R P R R P G P S D P A A P H A E L L R L G S H P A P A R A Q K P G S S G L A A R G L C V L G E D N A P L C-term A V D A W L V P L F F A A L M L L G L V G N S L V I Y V I C R H T V T N F Y I A N L A A T D V T F L L C C V P F T A L L Y G D F M C K F V N Y I Q Q V S V Q A T C A T L T A M S V D R W Y V T V F T P R L A L A V S L S I W V G S A A V S A P V L A L H S R A L E R A F A L Y N L L A L Y L L P L L A T C A C Y A A M L R H L G R V A V R P A P A D S A L Q G Q V L A E R A G A V R A K V S R L V A A V V L L F A A C W G P I Q L F L V L Q A L G S Y A A Y A L K T W A H C M S Y S N S A L N P L L Y A F L G S H F R R F R Q A V C P
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Residue Table


GPCRdb(A)
GPCRdb(A)
kisspeptin receptor
TM2
2x56 2.57x56 C95
2x59 2.60x59 F98
2x60 2.61x60 T99
ECL1
23x49 23.49x49 G107
TM3
3x28 3.28x28 V118
3x29 3.29x29 N119
3x32 3.32x32 Q122
3x33 3.33x33 Q123
3x36 3.36x36 V126
ECL2
45x50 45.50x50 C191
TM5
5x39 5.38x39 F204
5x43 5.42x43 N208
TM6
6x51 6.51x51 I279
6x52 6.52x52 Q280
6x54 6.54x54 F282
6x55 6.55x55 L283
6x58 6.58x58 Q286
TM7
7x27 7.28x27 S298
7x28 7.29x28 Y299
7x30 7.31x30 A301
7x31 7.32x31 Y302
7x34 7.35x34 K305
7x38 7.39x38 H309
7x42 7.43x42 Y313