PDB
8XIO
Resolution
2.7 Å
Released
July 3, 2024
Receptor
SST1
Class
A
Species
Homo sapiens
Ligand
L-797591
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
L-797591 L114 2.60x60 TM2 hydrophobic
L-797591 L134 3.29x29 TM3 hydrophobic
L-797591 A138 3.33x33 TM3 hydrophobic
L-797591 M141 3.36x36 TM3 hydrophobic
L-797591 I192 4.60x61 TM4 hydrophobic
L-797591 M210 45.52x52 ECL2 hydrophobic
L-797591 F223 5.38x39 TM5 aromatic (edge-to-face)
L-797591 W284 6.48x48 TM6 hydrophobic
L-797591 F287 6.51x51 TM6 hydrophobic
L-797591 Q291 6.55x55 TM6 polar (hydrogen bond)
L-797591 Q291 6.55x55 TM6 Van der Waals
L-797591 V309 7.39x38 TM7 hydrophobic
L-797591 V309 7.39x38 TM7 Van der Waals
L-797591 Y313 7.43x42 TM7 Van der Waals
L-797591 Y313 7.43x42 TM7 aromatic (face-to-face)

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ICL1 A K M K ICL1ECL1 R H W P F ECL1ICL2 P I K A A R Y R ICL2ECL2 R T A A N S D G T V A C N M L M P E ECL2ICL3 W Q Q R K R S ICL3ECL3 E Q D ECL3N-term M F P N G T A S S P S S S P S P S P G S C G E G G G S R G P G A G A A D G M E E P G R N A S Q N G T L S N-termC-term L S W M D N A A E E P V D Y Y A T A L K S R A Y S V E D F Q P E N L E S G G V F R N G T C T S R I T T L C-term E G Q G S A I L I S F I Y S V V C L V G L C G N S M V I Y V I L R Y T A T N I Y I L N L A I A D E L L M L S V P F L V T S T L L G A L L C R L V L S V D A V N M F T S I Y C L T V L S V D R Y V A V V H R P T V A K V V N L G V W V L S L L V I L P I V V F S P A Q R W L V G F V L Y T F L M G F L L P V G A I C L C Y V L I I A K M R M V A L K A G E R K I T L M V M M V V M V F V I C W M P F Y V V Q L V N V F A D A T V S Q L S V I L G Y A N S C A N P I L Y G F L S D N F Q R F K R S I L C
Helix box plot — Download: PNG | SVG S N G C L G V L C V V S Y I F S I L I A 1 L N L A I A D E L L M L S V P F L V T S 2 V T L C Y I S T F M N V A D V S L V L R 3 A K V V N L G V W V L S L L V I L P I 4 Y C L C I A G V P L L F G M L F T Y L V F 5 M M V V M V F V I C W M P F Y V V Q L V 6 I P N A C S N A Y G L I V S L Q S V T 7

GPCRdb(A)
GPCRdb(A)
SST1 receptor
TM2
2x60 2.60x60 L114
TM3
3x29 3.29x29 L134
3x33 3.33x33 A138
3x36 3.36x36 M141
TM4
4x61 4.60x61 I192
ECL2
45x52 45.52x52 M210
TM5
5x39 5.38x39 F223
TM6
6x48 6.48x48 W284
6x51 6.51x51 F287
6x55 6.55x55 Q291
TM7
7x38 7.39x38 V309
7x42 7.43x42 Y313