| Ligand | Amino Acid | Generic Number | Segment | Interaction Type |
|---|---|---|---|---|
| pasireotide | F113 | 2.59x59 | TM2 | hydrophobic |
| pasireotide | L114 | 2.60x60 | TM2 | hydrophobic |
| pasireotide | S117 | 2.63x63 | TM2 | polar (hydrogen bond) |
| pasireotide | S117 | 2.63x63 | TM2 | Van der Waals |
| pasireotide | V133 | 3.28x28 | TM3 | Van der Waals |
| pasireotide | L134 | 3.29x29 | TM3 | hydrophobic |
| pasireotide | L134 | 3.29x29 | TM3 | Van der Waals |
| pasireotide | D137 | 3.32x32 | TM3 | polar (charge-assisted hydrogen bond) |
| pasireotide | M141 | 3.36x36 | TM3 | Van der Waals |
| pasireotide | C208 | 45.50x50 | ECL2 | Van der Waals |
| pasireotide | N209 | 45.51x51 | ECL2 | Van der Waals |
| pasireotide | M210 | 45.52x52 | ECL2 | hydrophobic |
| pasireotide | M210 | 45.52x52 | ECL2 | Van der Waals |
| pasireotide | L220 | 5.35x36 | TM5 | hydrophobic |
| pasireotide | L220 | 5.35x36 | TM5 | Van der Waals |
| pasireotide | Q291 | 6.55x55 | TM6 | Van der Waals |
| pasireotide | Q291 | 6.55x55 | TM6 | polar (hydrogen bond) |
| pasireotide | D300 | ECL3 | polar (charge-assisted hydrogen bond) | |
| pasireotide | A302 | ECL3 | Van der Waals | |
| pasireotide | S305 | 7.35x34 | TM7 | Van der Waals |
| pasireotide | Q306 | 7.36x35 | TM7 | Van der Waals |
| pasireotide | Y313 | 7.43x42 | TM7 | Van der Waals |
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|
GPCRdb(A)
|
GPCRdb(A)
|
SST1 receptor
|
|---|---|---|
| TM2 | ||
| 2x59 | 2.59x59 | F113 |
| 2x60 | 2.60x60 | L114 |
| 2x63 | 2.63x63 | S117 |
| TM3 | ||
| 3x28 | 3.28x28 | V133 |
| 3x29 | 3.29x29 | L134 |
| 3x32 | 3.32x32 | D137 |
| 3x36 | 3.36x36 | M141 |
| ECL2 | ||
| 45x50 | 45.50x50 | C208 |
| 45x51 | 45.51x51 | N209 |
| 45x52 | 45.52x52 | M210 |
| TM5 | ||
| 5x36 | 5.35x36 | L220 |
| TM6 | ||
| 6x55 | 6.55x55 | Q291 |
| TM7 | ||
| 7x34 | 7.35x34 | S305 |
| 7x35 | 7.36x35 | Q306 |
| 7x42 | 7.43x42 | Y313 |