Structure information

SST3 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8XIR

SPECIES

Homo sapiens

RESOLUTION

2.520

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

July 3, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
004-DTR-LYS-TY5-PHE-A1D5E F99 2.59x59 TM2 hydrophobic
004-DTR-LYS-TY5-PHE-A1D5E L100 2.60x60 TM2 hydrophobic
004-DTR-LYS-TY5-PHE-A1D5E W109 23.50x50 ECL1 hydrophobic
004-DTR-LYS-TY5-PHE-A1D5E V119 3.28x28 TM3 hydrophobic
004-DTR-LYS-TY5-PHE-A1D5E M120 3.29x29 TM3 hydrophobic
004-DTR-LYS-TY5-PHE-A1D5E D123 3.32x32 TM3 polar (charge-assisted hydrogen bond)
004-DTR-LYS-TY5-PHE-A1D5E Q127 3.36x36 TM3 Van der Waals
004-DTR-LYS-TY5-PHE-A1D5E Q127 3.36x36 TM3 polar (hydrogen bond)
004-DTR-LYS-TY5-PHE-A1D5E C191 45.50x50 ECL2 Van der Waals
004-DTR-LYS-TY5-PHE-A1D5E H192 45.51x51 ECL2 Van der Waals
004-DTR-LYS-TY5-PHE-A1D5E M193 45.52x52 ECL2 Van der Waals
004-DTR-LYS-TY5-PHE-A1D5E M193 45.52x52 ECL2 hydrophobic
004-DTR-LYS-TY5-PHE-A1D5E W195 ECL2 Van der Waals
004-DTR-LYS-TY5-PHE-A1D5E W195 ECL2 hydrophobic
004-DTR-LYS-TY5-PHE-A1D5E R203 5.35x36 TM5 Van der Waals
004-DTR-LYS-TY5-PHE-A1D5E T210 5.42x43 TM5 Van der Waals
004-DTR-LYS-TY5-PHE-A1D5E F273 6.51x51 TM6 hydrophobic
004-DTR-LYS-TY5-PHE-A1D5E F273 6.51x51 TM6 Van der Waals
004-DTR-LYS-TY5-PHE-A1D5E L285 ECL3 Van der Waals
004-DTR-LYS-TY5-PHE-A1D5E L285 ECL3 polar (hydrogen bond with backbone)
004-DTR-LYS-TY5-PHE-A1D5E E287 ECL3 Van der Waals
004-DTR-LYS-TY5-PHE-A1D5E F291 7.31x30 TM7 Van der Waals
004-DTR-LYS-TY5-PHE-A1D5E F291 7.31x30 TM7 hydrophobic
004-DTR-LYS-TY5-PHE-A1D5E F292 7.32x31 TM7 Van der Waals
004-DTR-LYS-TY5-PHE-A1D5E F292 7.32x31 TM7 hydrophobic
004-DTR-LYS-TY5-PHE-A1D5E Y295 7.35x34 TM7 hydrophobic
004-DTR-LYS-TY5-PHE-A1D5E Y295 7.35x34 TM7 Van der Waals
004-DTR-LYS-TY5-PHE-A1D5E V299 7.39x38 TM7 Van der Waals
004-DTR-LYS-TY5-PHE-A1D5E V299 7.39x38 TM7 hydrophobic

Ligands

004-DTR-LYS-TY5-PHE-A1D5E

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Residue Diagrams

S N G L L G V V C V V L Y V L P I L V G 1 L N L A L A D E L F M L G L P F L A A Q 2 V T L C F I S T F Q N I G D V A M V L R 3 A R T V S A A V W V A S A V V V L P V 4 Y C L C I V L L P G F F G L A A T Y I I F 5 V A V V A L F V L C W M P F Y V L N I V 6 I P N A C S N A Y P L A V V L F Y L G 7
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ICL1 T A S P ICL1ECL1 Y W P F ECL1ICL2 P T R S A R W R ICL2ECL2 G V P R G M S T C H M Q W P E ECL2ICL3 W A P S C Q R ICL3ECL3 P L P E ECL3N-term M D M L H P S S V S T T S E P E N A S S A W P P D A T L G N V S A G P S P A G L A N-termC-term R P S R R V R S Q E P T V G P P E K T E E E D E E E E D G E E S R E G G K G K E M N G R V S Q I T Q P G T S G Q E R P P S R V A S K E Q Q L L P Q E A S T G E K S S T M R I S Y L C-term V S G V L I P L V Y L V V C V V G L L G N S L V I Y V V L R H S V T N V Y I L N L A L A D E L F M L G L P F L A A Q N A L S G S L M C R L V M A V D G I N Q F T S I F C L T V M S V D R Y L A V V H T A P V A R T V S A A V W V A S A V V V L P V V V F S P A A A W R A G F I I Y T A A L G F F G P L L V I C L C Y L L I V V K V R S A G R R V R R R S E R R V T R M V V A V V A L F V L C W M P F Y V L N I V N V V C E P A F F G L Y F L V V A L P Y A N S C A N P I L Y G F L S Y R F R R F K Q G V L L
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Residue Table


GPCRdb(A)
GPCRdb(A)
SST3 receptor
TM2
2x59 2.59x59 F99
2x60 2.60x60 L100
ECL1
23x50 23.50x50 W109
TM3
3x28 3.28x28 V119
3x29 3.29x29 M120
3x32 3.32x32 D123
3x36 3.36x36 Q127
ECL2
45x50 45.50x50 C191
45x51 45.51x51 H192
45x52 45.52x52 M193
TM5
5x36 5.35x36 R203
5x43 5.42x43 T210
TM6
6x51 6.51x51 F273
TM7
7x30 7.31x30 F291
7x31 7.32x31 F292
7x34 7.35x34 Y295
7x38 7.39x38 V299